Journal ArticleDOI
Transport mechanism of hydrophobic ions through lipid bilayer membranes.
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Evidence is presented that the transport of lipid-soluble ions through bilayer membranes occurs in three distinct steps: adsorption to the membranesolution interface; passage over an activation barrier to the opposite interface; and desorption into the aqueous solution.Abstract:
Evidence is presented that the transport of lipid-soluble ions through bilayer membranes occurs in three distinct steps: (1) adsorption to the membranesolution interface; (2) passage over an activation barrier to the opposite interface; and (3) desorption into the aqueous solution Support for this mechanism comes from a consideration of the potential energy of the ion, which has a minimum in the interface The formal analysis of the model shows that the rate constants of the individual transport steps can be determined from the relaxation of the electric current after a sudden change in the voltage Such relaxation experiments have been carried out with dipicrylamine and tetraphenylborate as permeable ions In both cases the rate-determining step is the jump from the adsorption site into the aqueous phase Furthermore, it has been found that with increasing ion concentration the membrane conductance goes through a maximum In accordance with the model recently developed by L J Bruner, this behavior is explained by a saturation of the interface, which leads to a blocking of the conductance at high concentrationsread more
Citations
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Journal ArticleDOI
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
TL;DR: In this article, mitochondria-targeted antioxidants have been developed by conjugating the lipophilic triphenylphosphonium cation to an antioxidant moiety, such as ubiquinol or α-tocopherol.
Journal ArticleDOI
Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.
Meredith F. Ross,Geoffrey F. Kelso,Frances H. Blaikie,Andrew M. James,Helena M. Cochemé,Aleksandra Filipovska,T Da Ros,Thomas R. Hurd,Robin A.J. Smith,Michael P. Murphy +9 more
TL;DR: Why Lipophilic phosphonium cations are useful in mitochondrial research and some of the ways in which they are now being utilized are outlined.
Journal ArticleDOI
Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems.
D.A. Haydon,Stephen B. Hladky +1 more
TL;DR: In this paper, a review of the role of 1-carriets in the transfer of ions across thin lipid bilayer membranes is presented, focusing on simpler systems, i.e., the lipid-soluble ions, the 1-1 carriets, a simple pore and a substance which prodeces interacting pores.
Journal ArticleDOI
Mitochondria-Targeted Small Molecule Therapeutics and Probes
TL;DR: The outstanding challenge in the area is to discover how to combine the established selective delivery to mitochondria with the specific delivery to particular organs.
References
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Synthesis of lecithins by acylation of O-(sn-glycero-3-phosphoryl) choline with fatty acid anhydrides
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The Solvation of Electrolytes in Dioxane-Water Mixtures, as Deduced from the Effect of Solvent Change on the Standard Partial Molar Free Energy1
Journal ArticleDOI
Electrical properties of bimolecular phospholipid membranes.
TL;DR: The electrical properties of bimolecular phospholipid membranes separating two aqueous electrolyte solutions were investivated and a steady membrane potential of nearly the limiting value was observed.
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