Journal ArticleDOI
Treatment of pterygium.
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TLDR
In conclusion, excision and adjunctive treatment with mitomycin C or conjunctival autograft is the most acceptable and most popular mode of treating both primary and recurrent pterygium.Abstract:
The treatment of ocular pterygium has been subjected to the development and application of various new strategies in the last few years. The worrisome problem of recurrence seems to have been significantly reduced with the newer methods of treatment. The field is however, still evolving. This review sets out to examine the various newer approaches to treating pterygium and in spite of the recent developments, to highlight the remaining challenges thereby suggesting the possible direction of future research. Also, to suggest treatment options for Ophthalmologists working in environments with limited resources. A library search and Internet search of PubMed and Google was conducted in 2010. Search terms included "pterygium in combination with surgery", "radiotherapy", "chemotherapy", "graft", and "recurrence." Abstracts were reviewed and relevant articles especially those published from the year 2000 to date were given more attention and when possible, reviewed in full. The relevant references in such articles were also reviewed. In conclusion, excision and adjunctive treatment with mitomycin C or conjunctival autograft is the most acceptable and most popular mode of treating both primary and recurrent pterygium. Outcomes seem to have been further improved with adjuvant combination therapy and the introduction of newer approaches to treatment.read more
Citations
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Journal ArticleDOI
Role of oxidative stress and vascular endothelial growth factor expression in pterygium pathogenesis and prevention of pterygium recurrence after surgical excision.
TL;DR: Oxidative stress and V EGF could play a role in the pathogenesis of pterygium as indicated by decreased antioxidant enzymatic activity and increased levels of VEGF in the pteryGium tissue and the role of MMC and anti-VEGF therapy in decreasing the recurrence rate after surgical excision.
Subconjunctival injection of bevacizumab for treatment of pterygium
TL;DR: Subconjunctival injection of 1.25 mg of bevacizumab given every 2 weeks for 10 weeks resulted in no significant change in size of the pterygium, however, local application of beVaczumab showed promise in inducing regression in pteryGium vascularity and thickness.
Journal ArticleDOI
Use of adjuvant hyperbaric oxygen therapy to support limbal conjunctival graft in the management of recurrent pterygium.
TL;DR: The use of HBOT together with excision and limbal conjunctival autograft for recurrent pterygium is associated with a low recurrence rate, and adjuvant HBOT should be considered in the surgical management of recurrent perygium.
Journal ArticleDOI
Dysregulated heme oxygenase-ferritin system in pterygium pathogenesis.
Timothy P. Fox,Katherine H. Gotlinger,Michael W. Dunn,Olivia L Lee,Tatyana Milman,Gerald W. Zaidman,Michal L. Schwartzman,Lars Bellner +7 more
TL;DR: It is believed that a dysfunctional HO–ferritin system leads to increased levels of proinflammatory mediators, thus contributing to the inflammation characteristic of pterygia.
Journal ArticleDOI
Surgical result of pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation
TL;DR: Pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation results in low recurrence, satisfactory cosmetic results and a low incidence of additional complications.
References
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Journal ArticleDOI
Serious Complications of Topical Mitomycin-C after Pterygium Surgery
Roy S. Rubinfeld,Roy S. Rubinfeld,Roswell R. Pfister,Raymond M. Stein,C. Stephen Foster,Neil F. Martin,Neil F. Martin,Neil F. Martin,Samuel Stoleru,Samuel Stoleru,Audrey R. Talley,Mark G. Speaker +11 more
TL;DR: If mitomycin is used, the lowest possible concentration should be applied for the shortest time period in an effort to avoid these complications and the authors urge extreme caution in the use of this medication.
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Comparison of Conjunctival Autografts, Amniotic Membrane Grafts, and Primary Closure for Pterygium Excision
TL;DR: The relatively low recurrence rate for primary pterygia allows one to use amniotic membrane transplantation as an alternative first choice, especially for advanced cases with bilateral heads or those who might need glaucoma surgery later.
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Conjunctival autograft transplantation for advanced and recurrent pterygium
TL;DR: Free conjunctival grafts from the superotemporal bulbar conjunctiva of the same eye were used to resurface exposed sclera and extraocular muscle and, in all 14 patients with diplopia, extraocular movement was restored and the surgical approach is recommended as a safe and effective means of treating pterygia complicated by Conjunctival scarring withextraocular muscle involvement and requiring concurrent fornix reconstruction.
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Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases
TL;DR: The current knowledge on pterygium pathogenesis is summarised, highlighting recent developments and novel data is provided further demonstrating the complexity of this intriguing disease.
Journal ArticleDOI
The Treatment Of Pterygium
TL;DR: It will be important to develop a grading system, and surgeons will need to be conservative in the treatment of pterygium until such time as a single treatment provides a lower recurrence rate and complication rate.