Journal ArticleDOI
Trends in the use of ultrasound-mediated transdermal drug delivery.
About:
This article is published in Drug Discovery Today.The article was published on 2004-10-01. It has received 21 citations till now. The article focuses on the topics: Sonophoresis & Transdermal.read more
Citations
More filters
Journal ArticleDOI
Overview of Therapeutic Ultrasound Applications and Safety Considerations
Douglas L. Miller,Nadine Barrie Smith,Michael R. Bailey,Gregory J. Czarnota,Kullervo Hynynen,Inder Raj S. Makin +5 more
TL;DR: The Bioeffects Committee of the American Institute of Ultrasound in Medicine outlines the wide range of therapeutic ultrasound methods, which are in clinical use or under study, and provides general guidance for ensuring therapeutic ultrasound safety.
Journal ArticleDOI
Ultrasound-Mediated Transdermal Drug Delivery
TL;DR: This review presents the main findings in the field of sonophoresis inTransdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field and pays particular attention to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy.
Journal ArticleDOI
Recent advances in ultrasound-based transdermal drug delivery
TL;DR: These areas include the sonophoretic application of various drugs, dual-frequency sonophoresis, synergistic combinations of transdermal drug delivery techniques, and the use of nanosized carriers in ultrasound-basedtransdermal delivery.
Journal ArticleDOI
DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell Lines
Yukihiro Furusawa,Yoshisada Fujiwara,Paul Campbell,Qing-Li Zhao,Ryohei Ogawa,Mariame A. Hassan,Yoshiaki Tabuchi,Ichiro Takasaki,Akihisa Takahashi,Takashi Kondo +9 more
TL;DR: By a combination of specific assays, it is demonstrated for the first time that US exposure at even moderate intensities exhibits genotoxic potential, through its facility to generate DNA damage across multiple cancer lines.
Journal ArticleDOI
Clinical evaluation of a continuous minimally invasive glucose flux sensor placed over ultrasonically permeated skin.
TL;DR: Continuous monitoring of glucose flux through ultrasonically permeable skin is safe and feasible and results in improved conductance in all patients.
References
More filters
Journal ArticleDOI
Ultrasound-mediated transdermal protein delivery.
TL;DR: Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible.
Journal ArticleDOI
Transdermal monitoring of glucose and other analytes using ultrasound.
Joseph Kost,Joseph Kost,Samir Mitragotri,Robert A. Gabbay,Robert A. Gabbay,Michael V. Pishko,Robert Langer +6 more
TL;DR: Here, it is sought to determine whether such ultrasound facilitates the outward transport of analytes present in the interstitial fluid, thereby allowing noninvasive extraction of clinically useful analytes 12.
Journal ArticleDOI
Ultrasound and transdermal drug delivery.
Ilana Lavon,Joseph Kost +1 more
TL;DR: This review presents the main findings in the field of sonophoresis, namelyTransdermal drug delivery and transdermal monitoring, with particular attention paid to proposed enhancement mechanisms and future trends in theField of cutaneous vaccination and gene delivery.
Journal ArticleDOI
Effect of sonication parameters on transdermal delivery of insulin to hairless rats
TL;DR: The findings indicated that sonophoretic enhancement is dependent on energy dose and length of ultrasound pulse that is consistent with a cavitation-based mechanism and may potentially be applied for non-invasive and painless delivery of insulin in the treatment of insulin-dependent diabetes.
Journal ArticleDOI
Rapid onset of cutaneous anesthesia with EMLA cream after pretreatment with a new ultrasound-emitting device.
TL;DR: Low-frequency ultrasound pretreatment appears to be safe and effective in producing rapid onset of EMLA cream in this model, with results as early as 5 min.