Journal ArticleDOI
Trigeminal nervous system sensitization by infraorbital nerve injury enhances responses in a migraine model.
Midori Toyama,Chiho Kudo,Chikako Mukai,Mika Inoue,Aiko Oyamaguchi,Hiroshi Hanamoto,Mitsutaka Sugimura,Hitoshi Niwa +7 more
TLDR
It is shown for the first time that the existence of the central sensitization of V2 can be an exacerbating factor for migraine related nociceptive thresholds/activation.Abstract:
BackgroundAlthough the peripheral and central sensitizations of trigeminal nervous system may be one of the important factors of migraine, the precise mechanism is not fully understood. In this stu...read more
Citations
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modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury.
Andrew D. Sauerbeck,Claudia Fanizzi,Claudia Fanizzi,Joong Hee Kim,Mihika Gangolli,Philip V. Bayly,Cheryl L. Wellington,David L. Brody,Terrance T. Kummer +8 more
TL;DR: A tunable, monitored model of murine non-surgical, diffuse closed-head injury characterized by impact as well as linear and rotational acceleration, modCHIMERA is reported, which should provide a reliable platform for efficient analysis of TBI pathophysiology and testing of treatment modalities.
Journal ArticleDOI
Animal models of pain and migraine in drug discovery.
TL;DR: Recent advances within these disciplines suggest that the relative value in terms of resources used, reciprocal flow of information and net worth of a 'typical' package could be increased substantially for the pain and migraine fields.
Journal ArticleDOI
Latent Sensitization in a Mouse Model of Ocular Neuropathic Pain.
Jooyoung Cho,Nicholas Bell,Gregory Botzet,Paras Vora,Benjamin J. Fowler,Renee R. Donahue,Heather M. Bush,Bradley K. Taylor,Bradley K. Taylor,Romulo Albuquerque +9 more
TL;DR: A murine model of corneal surface injury (CSI)–induced chronic ocular neuropathic pain is introduced and LS is established as a new inhibitory mechanism in the oculotrigeminal system and may be used for potential diagnostic and therapeutic interventions for ocular Neuropathy.
Journal ArticleDOI
Distal infraorbital nerve injury: a model for persistent facial pain in mice.
TL;DR: The results suggest that mice with DIONI develop strong aversive memories and some cognitive inflexibility, but create adaptive strategies to cope with the persistent trigeminal hypersensitivity.
Journal ArticleDOI
Preceding Administration of Minocycline Suppresses Plastic Changes in Cortical Excitatory Propagation in the Model Rat With Partial Infraorbital Nerve Ligation.
TL;DR: It is suggested that somatosensory and insular cortical excitation is changed by pl-ION, and the preceding injection of minocycline counteracts the plastic changes in the cortical activities.
References
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Journal ArticleDOI
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.
Gary J. Bennett,Y.-K. Xie +1 more
TL;DR: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve and the postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain were produced.
Journal ArticleDOI
The MAPK signaling cascade.
Rony Seger,Edwin G. Krebs +1 more
TL;DR: This review highlights primarily the first MAPK cascade to be discovered that uses the MEK and ERK isoforms and describes their involvement in different cellular processes, and it is now known that signaling pathways initiated by phorbol esters, iono‐phors, heat shock, and liganda for seven transmembrane receptors use distinct MAPK cascades with little or no cross‐reactivity between them.
Journal ArticleDOI
The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states.
TL;DR: Results indicate that NMDA receptors are involved in the induction and maintenance of the central sensitization produced by high threshold primary afferent inputs and have a bearing both on the potential role of NMDA antagonists for pre‐emptive analgesia and for treating established pain states.
Journal ArticleDOI
P2x4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Makoto Tsuda,Yukari Shigemoto-Mogami,Schuichi Koizumi,Akito Mizokoshi,Shinichi Kohsaka,Michael W. Salter,Kazuhide Inoue +6 more
TL;DR: It is demonstrated that activation of P2X4Rs in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactileAllodynia in normal animals, suggesting that blocking P1X4 receptors in microglial might be a new therapeutic strategy for pain induced by nerve injury.
Journal ArticleDOI
An association between migraine and cutaneous allodynia
Rami Burstein,Rami Burstein,David Yarnitsky,Itay Goor-Aryeh,Bernard J. Ransil,Zahid H. Bajwa +5 more
TL;DR: These findings suggest that the pathophysiology of migraine involves not only irritation of meningeal perivascular pain fibers but also a transient increase in the responsiveness of central pain neurons that process information arising from intracranial structures and skin.