Journal ArticleDOI
Tunable TACN/pyrazolate hybrid ligands as dinucleating scaffolds for metallobiosite modeling—dinickel(II) complexes relevant to the urease active site
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TLDR
Two dinucleating pyrazole ligands HL1 and HL2 bearing 1,4-diisopropyl-1,4,7-triazacyclononane (iPr2TACN) side arms in the 3 and 5 positions have been synthesized by multi-step synthetic procedures as mentioned in this paper.About:
This article is published in Inorganica Chimica Acta.The article was published on 2002-09-26. It has received 69 citations till now. The article focuses on the topics: Pyrazole & Cyanate.read more
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Journal ArticleDOI
Polynuclear transition metal complexes of metal⋯metal-bridging compartmental pyrazolate ligands
TL;DR: In this paper, the structures and properties of di-, oligo- and polynuclear transition metal complexes of substituted pyrazolate (pz) ligands with ligating side arms are reviewed.
Journal ArticleDOI
CO Insertion Reactions into the M−OH Bonds of Monomeric Nickel and Palladium Hydroxides. Reversible Decarbonylation of a Hydroxycarbonyl Palladium Complex
TL;DR: The binuclear CO2 complexes [M{C6H3-2,6-(CH2PiPr2)2}]2(μ-CO2-κ2C,O) (M = Ni, Pd) were formed via the formation of the Pd derivative via the mononuclear species Pd(COOH), which is stable under a CO atmosphere but reversibly loses CO and H2O on attempted isolation as discussed by the authors.
Journal ArticleDOI
Effect of Zn...Zn separation on the hydrolytic activity of model dizinc phosphodiesterases.
TL;DR: Comparative reactivity studies on the cleavage of bis(4-nitrophenyl)phosphate mediated by the two dizinc complexes have revealed that the system with the larger Zn...Zn separation is hydrolytically more potent, both in the hydrolysis and the transesterification of BNPP.
Journal ArticleDOI
Correlation of Structure and Function in Oligonuclear Zinc(II) Model Phosphatases
Bernhard Bauer-Siebenlist,Franc Meyer,Etelka Farkas,Denis Vidovic,Jose A. Cuesta-Seijo,Regine Herbst-Irmer,Hans Pritzkow +6 more
TL;DR: A series of pyrazolate-based dizinc(II) complexes has been synthesized and investigated as functional models for phosphoesterases, focusing on correlations between hydrolytic activity and molecular parameters of the bimetallic core.
Journal ArticleDOI
Nickel Complexes of Carboxylate-Containing Polydentate Ligands as Models for the Active Site of Urease
TL;DR: In this assay, complexes based on the asymmetric ligand ICIMP exhibit a significantly faster rate of hydrolysis than the corresponding BCIMP complexes.
References
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Book ChapterDOI
SHELXL: high-resolution refinement.
TL;DR: The program is designed to be easy to use and general for all space groups and uses a conventional structure-factor calculation rather than a fast Fourier transform (FFT) summation, which is much slower than programs written specifically for macromolecules.
Journal ArticleDOI
Letter: Jack bean urease (EC 3.5.1.5). A metalloenzyme. A simple biological role for nickel?
Journal ArticleDOI
The crystal structure of urease from Klebsiella aerogenes
TL;DR: A surprisingly high structural similarity between the urease catalytic domain and that of the zinc-dependent adenosine deaminase reveals a remarkable example of active site divergence.
Journal ArticleDOI
Supramolecular assembly and acid resistance of Helicobacter pylori urease.
TL;DR: The crystal structure of H. pylori urease is determined and provides a novel example of a molecular assembly adapted for acid resistance that, together with the low Km value of the enzyme, is likely to enable the organism to inhabit the hostile niche.
Journal ArticleDOI
A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels.
Stefano Benini,Wojciech Rypniewski,Keith S. Wilson,Silvia Miletti,Stefano Ciurli,Stefano Mangani +5 more
TL;DR: The mode of binding of the inhibitor, and a comparison between the native and inhibited urease structures, indicate a novel mechanism for enzymatic urea hydrolysis which reconciles the available structural and biochemical data.
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