Journal ArticleDOI
Ultrasound characterization of normal ocular tissue in the frequency range from 50 MHz to 100 MHz
TLDR
The ultrasonic properties of ocular tissues including sclera, cornea, ciliary body and iris have been quantitatively evaluated over the frequency range from 50 MHz to 100 MHz at 37/spl deg/C and are qualitatively related to their histological structure and imaging characteristics.Abstract:
The ultrasonic properties of ocular tissues including sclera, cornea, ciliary body and iris have been quantitatively evaluated over the frequency range from 50 MHz to 100 MHz at 37/spl deg/C. Measurements were made with a wideband 60 MHz PVDF copolymer transducer in conjunction with a C-scan microscopy system developed in the authors' laboratory. Using this system, high resolution overview images were produced to identify homogeneous tissue regions for detailed quantitative analysis. The speed of sound for the four eye tissues ranged from 1542 m/s for iris to 1622 m/s for sclera. At 50 MHz the attenuation coefficient ranged from 1.3 dB/mm for cornea to 4.3 dB/mm for sclera. Scleral tissue also had the highest backscatter coefficient (0.0157 Sr/sup -1/ mm/sup -1/), while iris had the lowest (0.00184 Sr/sup -1/ mm/sup -1/). The measured ultrasonic properties are qualitatively related to their histological structure and imaging characteristics. >read more
Citations
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Journal ArticleDOI
Advances in ultrasound biomicroscopy
TL;DR: Aspects of transducer development, systems design and tissue properties are presented to provide a foundation for medical and biological applications and speculation on the continuing evolution of ultrasound biomicroscopy is discussed.
Journal ArticleDOI
Biomechanics of the Human Posterior Sclera: Age- and Glaucoma-Related Changes Measured Using Inflation Testing
Baptiste Coudrillier,Jing Tian,Stephen Alexander,Kristin M. Myers,Harry A. Quigley,Thao D. Nguyen +5 more
TL;DR: Differences in the biomechanical response of normal and glaucoma sclera may represent baseline properties that contribute to axon damage, or may be characteristics that result fromglaucomatous disease.
Journal ArticleDOI
Epithelial Thickness in the Normal Cornea: Three-dimensional Display With Very High Frequency Ultrasound
TL;DR: Three-dimensional thickness mapping of the corneal epithelium demonstrated that the epithelial thickness is not evenly distributed across the cornea; the epithelia was significantly thicker inferiorly than superiorly and significantly thicker nasally than temporally with a larger inferosuperior difference than nasotemporal difference.
Journal ArticleDOI
Stromal Thickness in the Normal Cornea: Three-dimensional Display With Artemis Very High-frequency Digital Ultrasound
TL;DR: Three-dimensional thickness mapping of the corneal stroma and stromal thickness progression in a population of normal eyes represent a normative data set, which may help in early diagnosis of cornea abnormalities such as keratoconus and pellucid marginal degeneration.
Journal ArticleDOI
A history of medical and biological imaging with polyvinylidene fluoride (PVDF) transducers
TL;DR: The exploitation of PVDF as a transducer material from its early beginnings for thyroid and breast imaging to its current well-established applications in ultrasound biomicroscopy is traced.
References
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Journal ArticleDOI
Comprehensive compilation of empirical ultrasonic properties of mammalian tissues
TL;DR: A detailed review of the literature on ultrasonic propagation properties of mammalian tissues and organs has revealed 144 papers containing compilable data, including over 1300 lines of parametric data.
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Clinical use of ultrasound biomicroscopy
TL;DR: Clinical ultrasound biomicroscopy (UBM) has shown significant potential as an aid in diagnoses of ocular disease and the ability to define the relationship of the iris, posterior chamber, zonules, ciliary body, and lens is potentially helpful in understanding mechanisms of glaucoma.
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Relationship of Ultrasonic Spectral Parameters to Features of Tissue Microstructure
TL;DR: Three models of tissue microstructure were considered, and calibrated power spectra were computed for a series of scatterer sizes, concentrations, and acoustic impedances to simulate studies of the eye and liver.
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Compilation of empirical ultrasonic properties of mammalian tissues. II
TL;DR: The compilation of the literature on ultrasonic propagation properties of mammalian tissues is continued with the addition of 45 papers yielding over 700 lines of parametric data.