Journal ArticleDOI
Ultrasound-induced changes in rates of influx and efflux of potassium ions in rat thymocytes in vitro.
TLDR
It is demonstrated that the potassium content of rat thymocytes in vitro is decreased following exposure to 2W/cm 2, 3MHz ultrasound for 40 min at 37°C, without inducing cell lysis or gross membrane damage.Abstract:
It is demonstrated that the potassium content of rat thymocytes in vitro is decreased following exposure to 2W/cm 2 , 3MHz ultrasound for 40 min at 37°C, without inducing cell lysis or gross membrane damage. The abnormal values for potassium are maintained after completion of insonation. The changes are shown to arise from ultrasound-induced decreases in ion influx together with increases in potassium efflux. Recorded temperature changes in the media are shown to be insufficient to account for the observed decreases in cell potassium. The magnitude of cell potassium decrease at 3 MHz is shown to be similar in aerated and degassed water. Acoustic microstreaming either at the cell membrane of within the cell is suggested as the damage mechanism leading to ion flux changes.read more
Citations
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Journal ArticleDOI
Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.
TL;DR: This study confirms earlier animal and clinical studies that demonstrated the efficacy of low-intensity ultrasound stimulation in the acceleration of the normal fracture-repair process.
Journal ArticleDOI
A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective
TL;DR: This selective review of the biological effects of ultrasound presents a synopsis of the current understanding of how cells insonated in vitro are affected by inertial cavitation from the standpoint of physical and chemical mechanisms.
Journal ArticleDOI
Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound.
William J. Tyler,Yusuf Tufail,Michael Finsterwald,Monica L. Tauchmann,Emily J. Olson,Cassondra Majestic +5 more
TL;DR: It is concluded US provides a powerful tool for remotely modulating brain circuit activity by transmitting US waveforms through hippocampal slice cultures and ex vivo mouse brains and can stimulate electrical activity and calcium signaling in neurons as well as central synaptic transmission.
Journal ArticleDOI
The use of low-intensity ultrasound to accelerate the healing of fractures.
TL;DR: The case is made that nature's process of fracture-healing, while elegant, can be accelerated with respect to achieving the ability to support clinically relevant loads.
Journal ArticleDOI
The enhancement of bone regeneration by ultrasound
Lutz Claes,Bettina M. Willie +1 more
TL;DR: Clinical and experimental studies demonstrating the enhancing effect of LIPUS on bone regeneration, the biophysical mechanisms involved in the complex fracture healing process remain unclear and requires further research.
References
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Journal ArticleDOI
Physical and chemical aspects of ultrasonic disruption of cells.
P. R. Clarke,C. R. Hill +1 more
TL;DR: Although prolonged sonication of the medium can eventually reduce its ability to support cells, such indirect effect is insignificant the relatively short irradiation times required to kill 99% of cells and the primary mechanism of damage here appears to be mechanical.
Journal ArticleDOI
On Cavity Formation in Water
TL;DR: In this article, high speed motion photography of the rapid movement of a glass rod (5 mm diameter) in a narrow (16 mm inside diameter) glass tube of water was used to study the tensile strength of water.
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Ultrasonic Exposure Thresholds for Changes in Cells and Tissues
TL;DR: In this paper, the authors reported a dependence of stable cavitation on intensity, frequency, pulsing parameters, ambient pressure, and nature of the medium (liquid, gel, or organized tissue).
Journal ArticleDOI
Hemolysis near a transversely oscillating wire.
TL;DR: Erythrocyte suspensions were subjected to hydrodynamic forces generated by a partially submerged tungsten wire set into transverse oscillation at 20 kilohertz and free hemoglobin appears in solution when the oscillation amplitude exceeds a critical threshold value.