Ultraviolet-a light and riboflavin therapy for acanthamoeba keratitis: a case report.
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TLDR
Treatment with UV-A light was an effective therapy in this case of AK, with improvement of symptoms, visual acuity, and biomicroscopy cornea with haze degree I.Abstract:
Purpose: To report ultraviolet-A (UV-A) light treatment in a patient with Acanthamoeba keratitis (AK). Methods: Interventional case report. A standard protocol for ultraviolet corneal therapy, with a power emission of 3 mW/cm2 and a wavelength of 370 nm, was used. The protocol included an 8-nm bandwidth at a 54-mm distance measured with a collimation system of diodes as well as a protective shield of riboflavin in a case of documented AK. Results: A 54-year-old female patient with AK, showing no therapeutic response to a wide variety of topical antimicrobial agents and with a visual acuity of 20/400, was treated with UV-A therapy. The patient displayed a favourable response in the first 24 h after treatment, with improvement of symptoms, visual acuity (to 20/200) and biomicroscopy cornea with haze degree I. By the third week post-treatment, the patient was symptom-free. Her visual acuity was 20/30, and the affected cornea was clear. Five months after treatment, there had been no recurrence, and her vision was 20/20. Conclusions: Treatment with UV-A light was an effective therapy in this case of AK.read more
Citations
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Journal ArticleDOI
An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment
TL;DR: Novel molecular approaches such as proteomics, RNAi and a consensus in the diagnostic approaches for a suspected case of Acanthamoeba keratitis are proposed and reviewed based on data which have been compiled after years of working on this amoebic organism.
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Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting.
Dalia G Said,Mohamed Elalfy,Zisis Gatzioufas,Ehab S. El-Zakzouk,Mansour Hassan,Mohamed Yasser Sayed Saif,Ahmed A. Zaki,Harminder S Dua,Farhad Hafezi,Farhad Hafezi +9 more
TL;DR: Corneal CXL with photoactivated riboflavin did not shorten the time to corneal healing; however, the complication rate was 21% in the control group, whereas there was no incidence of corneals perforation or recurrence of the infection in the PACK-CXL group.
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Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes.
TL;DR: Early diagnosis and treatment are required to effectively manage this condition and there is often a poor prognosis because of a significant delay in diagnosis and frequently a lack of effective medical management.
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Pathogenesis of microbial keratitis
TL;DR: The treatment of microbial keratitis should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue.
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Corneal Collagen Cross-Linking for Infectious Keratitis: A Systematic Review and Meta-Analysis.
TL;DR: CXL seems promising in the management of infectious keratitis, excluding viral infections, however, more randomized controlled trials are required to assess its efficacy.
References
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Journal ArticleDOI
Safety of UVA-riboflavin cross-linking of the cornea.
TL;DR: Comparison of the currently used riboflavin/UVA approach with officially accepted guidelines regarding direct UV damage and the damage created by the induced free radicals shows that as long as the cornea treated has a minimum thickness of 400 μm, the corneal endothelium will not experience damage, nor will deeper structures such as lens and retina.
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Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts
TL;DR: CXL is a promising option for treating patients with therapy-refractory infectious keratitis to avoid emergency keratoplasty, and the progression of corneal melting was halted after CXL treatment.
Journal ArticleDOI
Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases.
Yasin A. Khan,Renata T. Kashiwabuchi,Suy Anne R. Martins,J. Castro-Combs,Sachin Kalyani,Philip F Stanley,David Flikier,Ashley Behrens +7 more
TL;DR: The adjunctive use of UVA and B2 therapy seems to be a possible alternative for selected cases of medication-resistant AK.
Journal ArticleDOI
Riboflavin and ultraviolet a collagen crosslinking of the cornea for the treatment of keratitis.
TL;DR: Until more data are available this treatment should only be considered in therapy-refractive keratitis or ulceration and not in the first line of defence since it may have cytotoxic side effects.
Journal ArticleDOI
UV Inactivation of Cryptosporidium hominis as Measured in Cell Culture
Anne M. Johnson,Karl G. Linden,Kristina M. Ciociola,Ricardo León,Giovanni Widmer,Paul A. Rochelle +5 more
TL;DR: This study utilized cell culture-based methods to demonstrate that C. hominis oocysts displayed similar levels of infectivity and had the same sensitivity to UV light as C. parvum.