Journal ArticleDOI
Urinary organic acids found in b6‐deficient rats and calcium oxalate calculus patients1
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TLDR
Both B6–deficient rats and hyperoxaluric patients respond to tyrosine administration by a drop in urinary oxalate, and that hydroxy-proline is a major source seems a probable explanation for changes in oxalic acid excretion with stress.Abstract:
SUMMARY
1
B6-deficient rats and calcium oxalate stone-forming patients share several metabolic abnormalities.
2
In our experiments, evidence for folic acid deficiency in the stone patients is strong, and some evidence exists in B6–deficient rats as well.
3
Susceptibility to overload of the acetyl coenzyme A system is high in both.
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Sources of oxalic acid probably include aromatic amino acid derivatives with a 3 carbon side chain, whose metabolism is blocked by tyrosine, and whose dependence on the acetyl coenzyme A system is shown by the simultaneous drop in oxalate, hippurate, α-ketoglutarate and citric acids. That hydroxy-proline is a major source seems a probable explanation for changes in oxalate excretion with stress.
5
Both B6–deficient rats and hyperoxaluric patients respond to tyrosine administration by a drop in urinary oxalate.read more
Citations
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Journal ArticleDOI
Molecular aspects of idiopathic urolithiasis
Journal ArticleDOI
1 H NMR-based metabolomic study of metabolic profiling for the urine of kidney stone patients
TL;DR: A preliminary metabolic profiling of the urine from kidney stone patients via using 1H NMR-based analytical techniques for the first time is established and provided a novel method for recognizing and observing the kidney stone disease.
Journal ArticleDOI
Plasma levels and urinary excretion of amino acids by subjects with renal calculi.
TL;DR: There is a general tendency towards decreased amino acid excretions in all SFs with all types of stones, and as a whole, one can observe a higher percentage of patients with calcium oxalate and phosphate calculosis, who have low urine excretion of amino acids.
References
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Journal ArticleDOI
The assay of aromatic amino acid transaminations and keto acid oxidation by the enol borate-tautomerase method.
TL;DR: The enol tautomers of the aromatic oc-keto acids combine instantaneously and reversibly with borate to form complexes of a mixed ester-anhydride structure, thereby displacing the apparent keto-enol equilibrium in favor of the enl tautomer.
Book ChapterDOI
Transamination and the integrative functions of the dicarboxylic acids in nitrogen metabolism.
TL;DR: The conception of the dicarboxylic acid system as a central component of first order in the chemical integration of nitrogenous metabolism satisfactorily accounts for the widespread occurrence of transamination and for its exceptionally high activity in certain tissues.
Journal ArticleDOI
Conversion of gamma-hydroxyglutamate to glyoxylate and alanine; purification and properties of the enzyme system.
Eugene E. Dekker,Umadas Maitra +1 more
TL;DR: Examination of the enzyme system led us to propose a sequence of reactions, in which the net formation of glyoxylate and alanine from y-hydroxyglutamate occurred by a sequential loss of the amino group of an amino acid, followed by a cleavage and a reamination of one of the fragments, as illustrated in the following reactions.
Journal ArticleDOI
The Effects of an Induced Pyridoxine and Pantothenic Acid Deficiency on Excretions of Oxalic and Xanthurenic Acids in the Urine
Sandra R. Faber,Sandra R. Faber,Wende W. Feitler,Wende W. Feitler,Roberta E. Bleiler,Roberta E. Bleiler,Margaret A. Ohlson,Robert E. Hodges +7 more
TL;DR: It has now been shown in animals and in man that oxalic acid may be derived endogenously from glycine via glyoxvlic acid, and inhibition of this reaction, such as may occur in a lack of pyridoxine, could result in an ac- cumulation of glyoxylic acid with increased oxAlic acid production.