Journal ArticleDOI
Use of Statins and Risk of Fractures
TLDR
In this paper, a statin dosage of less than 20 mg/d (standardized to simvastatin) was associated with an adjusted OR of fracture of 1.13 (95% CI, 0.96-1.33).Abstract:
bral fractures, the ORs were 1.01 (95% CI, 0.80-1.27), 0.59 (95% CI, 0.31-1.13), and 1.15 (95% CI, 0.62-2.14), respectively. Relative to nonuse, a statin dosage of less than 20 mg/d (standardized to simvastatin) was associated with an adjusted OR of fracture of 1.13 (95% CI, 0.96-1.33); this OR was 1.07 (95% CI, 0.82-1.38) at dosages of 20 to 39.9 mg/d and 0.85 (95% CI, 0.47-1.53) at dosages of 40 mg/d or more. The adjusted OR was 0.71 (95% CI, 0.50-1.01) for statin use durations of 0 to 3 months, 1.31 (95% CI, 0.87-1.95) for durations of 3 to 6 months, 1.14 (95% CI, 0.82-1.58) for durations of 6 to 12 months, and 1.17 (95% CI, 0.99-1.40) for durations of more than 12 months. Conclusion In this study, use of statins at dosages prescribed in clinical practice was not associated with a reduction in risk of fracture. JAMA. 2001;285:1850-1855 www.jama.comread more
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Journal ArticleDOI
Immortal time bias in observational studies of drug effects
Samy Suissa,Samy Suissa +1 more
TL;DR: The bias from 20 cohort studies is described and illustrated by showing that unrelated drugs can be made to appear effective at treating cardiovascular disease (CVD) by way of immortal time bias.
Results of 4 Prospective Studies and Cumulative Meta-analysis of Observational Studies and Controlled Trials
Douglas C. Bauer,Greg R. Mundy,Sophie A. Jamal,Dennis M. Black,Jane A. Cauley,Kristine E. Ensrud,Marjolein van der Klift,Huibert A. P. Pols +7 more
TL;DR: Observational studies suggest that the risk for hip and nonspine fractures is lower among older women taking statin medications for hyperlipidemia, but post hoc analyses of cardiovascular trials do not.
Journal ArticleDOI
Statin Use, Clinical Fracture, and Bone Density in Postmenopausal Women: Results from the Women's Health Initiative Observational Study
Andrea Z. LaCroix,Jane A. Cauley,Mary Pettinger,Judith Hsia,Douglas C. Bauer,Joan McGowan,Zhao Chen,Cora E. Lewis,S. Gene McNeeley,Maureen D. Passaro,Rebecca D. Jackson +10 more
TL;DR: Examining the association of statin use with levels of bone density and rates of hip, lower arm or wrist, and other clinical fractures in the Women's Health Initiative cohort of postmenopausal women raised the possibility that statin treatment might prevent both coronary and fracture events, two major causes of morbidity in older women, later in life.
Journal ArticleDOI
Temporal trends in hip and knee replacement in the United Kingdom: 1991 TO 2006
TL;DR: The data support the notion that the rate of joint replacement is increasing in the United Kingdom with therate of TKR rising at the highest rate and the perception that the mean age for TKR has decreased over time is not supported.
Journal ArticleDOI
Representativeness and optimal use of body mass index (BMI) in the UK Clinical Practice Research Datalink (CPRD)
TL;DR: Completeness of BMI in CPRD increased over time and varied by age and sex; at a given point in time, a large proportion of the most recent BMIs are unlikely to reflect current BMI; consequent BMI misclassification might be reduced by employing model-based imputation of current BMI.