Journal ArticleDOI
Utilization and Outcomes of Temporary Mechanical Circulatory Support for Graft Dysfunction After Heart Transplantation.
Kevin Phan,Jessica G.Y. Luc,Joshua Xu,Simon Maltais,John M. Stulak,Tristan D. Yan,Vakhtang Tchantchaleishvili +6 more
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TLDR
No significant difference was found in pooled 30 day survival, survival to discharge, and overall survival between the subgroups, and temporary mechanical circulatory support is an effective modality to support patients with graft dysfunction after heart transplantation.Abstract:
Graft dysfunction is the main cause of early mortality after heart transplantation. In cases of severe graft dysfunction, temporary mechanical circulatory support (TMCS) may be necessary. The aim of this systematic review was to examine the utilization and outcomes of TMCS in patients with graft dysfunction after heart transplantation. Electronic search was performed to identify all studies in the English literature assessing the use of TMCS for graft dysfunction. All identified articles were systematically assessed for inclusion and exclusion criteria. Of the 5,462 studies identified, 41 studies were included. Among the 11,555 patients undergoing heart transplantation, 695 (6.0%) required TMCS with patients most often supported using venoarterial extracorporeal membrane oxygenation (79.4%) followed by right ventricular assist devices (11.1%), biventricular assist devices (BiVADs) (7.5%), and left ventricular assist devices (LVADs) (2.0%). Patients supported by LVADs were more likely to be supported longer (p = 0.003), have a higher death by cardiac event (p = 0.013) and retransplantation rate (p = 0.015). In contrast, patients supported with BiVAD and LVAD were more likely to be weaned off support (p = 0.020). Overall, no significant difference was found in pooled 30 day survival (p = 0.31), survival to discharge (p = 0.19), and overall survival (p = 0.51) between the subgroups. Temporary mechanical circulatory support is an effective modality to support patients with graft dysfunction after heart transplantation. Further studies are needed to establish the optimal threshold and strategy for TMCS and to augment cardiac recovery and long-term survival.read more
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Journal ArticleDOI
Registro Español de Trasplante Cardiaco. XXVIII Informe Oficial de la Sección de Insuficiencia Cardiaca de la Sociedad Española de Cardiología (1984-2016)
Francisco González-Vílchez,Manuel Gómez-Bueno,Luis Almenar-Bonet,María G. Crespo-Leiro,José María Arizón del Prado,Juan Delgado-Jiménez,Iago Sousa-Casasnovas,Vicens Brossa-Loidi,José Manuel Sobrino-Márquez,José González-Costelo +9 more
TL;DR: La actividad de trasplante cardiaco en Espana permanece estable en los ultimos anos, with alrededor of 250-300 procedimientos al ano, y una mejoria de la supervivencia ha aumentado significativamente en la ultima decada con respecto a periodos anteriores.
Journal ArticleDOI
Outcomes and survival following heart retransplantation for cardiac allograft failure: a systematic review and meta-analysis
Syed-Saif Abbas Rizvi,Jessica G.Y. Luc,Jae Hwan Choi,Kevin Phan,Ester Moncho Escrivá,Sinal Patel,H. Todd Massey,Vakhtang Tchantchaleishvili +7 more
TL;DR: Patients who underwent heart RTx had a significant lower survival when compared to those who only underwent primary HTx and there were no significant differences in post-transplantation freedom from rejection.
Journal ArticleDOI
Left Ventricular Assist Device Decommissioning Compared with Explantation for Ventricular Recovery: A Systematic Review.
Jae Hwan Choi,Matthew P. Weber,Dylan P. Horan,Jessica G.Y. Luc,Kevin Phan,Sinal Patel,Syed-Saif Abbas Rizvi,Elizabeth J. Maynes,Gordon R. Reeves,John W. Entwistle,Rohinton J. Morris,H. Todd Massey,Vakhtang Tchantchaleishvili +12 more
TL;DR: Decommissioning appears to be a feasible alternative to LVAD explantation in terms of overall patient outcomes, and there was a trend toward a higher recurrence of heart failure in patients who underwent decommissioning as compared withExplantation.
Journal ArticleDOI
Clinical implications of LDH isoenzymes in hemolysis and continuous-flow left ventricular assist device-induced thrombosis
Jonathan S. Gordon,Chelsey T. Wood,Jessica G.Y. Luc,Ryan A. Watson,Elizabeth J. Maynes,Jae Hwan Choi,Rohinton J. Morris,H.T. Massey,Amy L. Throckmorton,Vakhtang Tchantchaleishvili +9 more
TL;DR: The various isoenzymes of LDH are reviewed and their utility in differentiating hemolysis seen in CF-LVAD pump thrombosis from other physiologic and pathologic conditions as reported in the literature is reviewed.
Journal ArticleDOI
Extracorporeal Membrane Oxygenation after Heart Transplantation: Impact of Type of Cannulation.
Arash Mehdiani,Moritz Benjamin Immohr,Charlotte Boettger,Hannan Dalyanoglu,D. Scheiber,Ralf Westenfeld,Hug Aubin,Payam Akhyari,Diyar Saeed,Artur Lichtenberg,Udo Boeken +10 more
TL;DR: In patients supported for PGD, peripheral and central cannulation strategies are safe and feasible for prolonged venoarterial ECMO support and it is thought that aortic cannulation with tunneling of the cannula and closure of the chest could be a good option in patients with PGD after htx.
References
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Journal ArticleDOI
The registry of the international society for heart and lung transplantation: Thirtieth official adult heart transplant report - 2013; Focus theme: Age
Lars H. Lund,Leah B. Edwards,Anna Y. Kucheryavaya,Anne I. Dipchand,Christian Benden,Jason D. Christie,Fabienne Dobbels,Richard Kirk,Axel O. Rahmel,Roger D. Yusen,Josef Stehlik +10 more
TL;DR: This 30th adult heart transplant report is based on data submitted on 110,486 heart transplants in recipients of all ages by 407 centers worldwide since 1982 through June 30, 2012, with follow-up until June 30- 2012.
Journal ArticleDOI
Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation.
O.H. Frazier,Eric A. Rose,Mehmet C. Oz,Walter P. Dembitsky,Patrick M. McCarthy,Branislav Radovancevic,Victor L. Poirier,Kurt A. Dasse +7 more
TL;DR: The HeartMate VE LVAS provides adequate hemodynamic support, has an acceptably low incidence of adverse effects, and improves survival in heart transplant candidates both inside and outside the hospital.
Journal ArticleDOI
Report from a consensus conference on primary graft dysfunction after cardiac transplantation.
Jon A. Kobashigawa,Andreas Zuckermann,Peter S. Macdonald,Pascal Leprince,Fardad Esmailian,Minh B. Luu,Donna Mancini,Jignesh Patel,Rabia R. Razi,Hermann Reichenspurner,Stuart D. Russell,Javier Segovia,N. Smedira,Josef Stehlik,Florian Wagner +14 more
TL;DR: A consensus conference was organized to better define, diagnose, and manage primary graft dysfunction (PGD), with the aim of leading to better understanding of PGD and prevention/minimization of its adverse outcomes.
Journal ArticleDOI
Clinical experience with 202 adults receiving extracorporeal membrane oxygenation for cardiac failure: Survival at five years
Nicholas G. Smedira,Nader Moazami,Camille M. Golding,Patrick M. McCarthy,Carolyn Apperson-Hansen,Eugene H. Blackstone,Delos M. Cosgrove +6 more
TL;DR: Extracorporeal membrane oxygenation is versatile and salvages some patients who would otherwise die, but improvement in intermediate-term outcome will require a multidisciplinary approach to protect organ function and limit organ injury before and during this support.
Journal ArticleDOI
Multicenter clinical evaluation of the heartmate; vented electric left ventricular assist system in patients awaiting heart transplantation.
O.H. Frazier,Eric A. Rose,Mehmet C. Oz,Walter P. Dembitsky,Patrick M. McCarthy,Branislav Radovancevic,Victor L. Poirier,Kurt A. Dasse +7 more
TL;DR: In this paper, a prospective, multicenter clinical trial conducted at 24 centers in the United States, 280 transplant candidates (232 men, 48 women; median age, 55 years; range, 11-72 years) unresponsive to inotropic drugs, intra-aortic balloon counterpulsation, or both, were treated with the HeartMate Vented Electric Left Ventricular Assist System (VE LVAS).