Journal ArticleDOI
Utilization of whey powder as an alternate carbon source for production of hypocholesterolemic drug by Aspergillus terreus MTCC 1281
Reads0
Chats0
TLDR
In this paper, the authors investigated the utilization of whey powder as an alternate carbon source and statistical optimization of medium components on lovastatin production by Aspergillus terreus MTCC 1281.Abstract:
In this present study, we investigated the utilization of whey powder as an alternate carbon source and statistical optimization of medium components on lovastatin production by Aspergillus terreus MTCC 1281. Central composite design (CCD) of response surface methodology (RSM) was successfully employed to optimize the four medium variables whey powder, yeast extract, sodium chloride, and copper sulphate at five levels. Regression analysis explained that the linear and square effects of the variables were found significant with R2 value of 0.937. Maximum lovastatin production of 358.2 mg/L was obtained with the predicted optimal concentration of whey powder 1.5%, yeast extract 0.75%, sodium chloride 0.04%, and copper sulphate 0.019%.The results of this study indicated that statistical optimization approach leads to high lovastatin production by using whey powder as a carbon source.read more
Citations
More filters
Journal ArticleDOI
Waste derivitized blue luminescent carbon quantum dots for selenite sensing in water.
TL;DR: An environmental friendly, facile, and completely green synthetic method for producing carbon quantum dots from whey, a major dairy waste, and the functionalized GCQDs probe is shown to detect selenite with high sensitivity in 10-1000ppb detection range.
Journal ArticleDOI
Growth profiling, kinetics and substrate utilization of low-cost dairy waste for production of β-cryptoxanthin by Kocuria marina DAGII
Ruchira Mitra,Debjani Dutta +1 more
TL;DR: Detailed kinetic analysis of cellular growth, substrate consumption and product formation revealed that growth inhibition took place at substrate concentrations higher than 12% (v/v) of cheese whey, and the Han and Levenspiel model was the best fitted substrate inhibition model.
Journal ArticleDOI
Optimization of date syrup as a novel medium for lovastatin production by Aspergillus terreus ATCC 20542 and analyzing assimilation kinetic of carbohydrates
TL;DR: Glucose and fructose assimilation kinetic parameters revealed that more lovastatin is produced during glucose assimilation, while more biomass was formed during fructose Assimilation.
Journal ArticleDOI
A Review of the Effective Factors for Lovastatin Production by Aspergillus Terreus Atcc 20542 in Liquid Submerged Fermentation
TL;DR: The study shows, the source of carbon and nitrogen, the C/N, the amount and type of inoculation, pH, minerals and inducer are the most important factors affecting the morphology and oxygen uptake by the, Aspergillus terreus and hence also affect the production of lovastatin.
Journal ArticleDOI
Lovastatin Production from Aspergillus Terreus ATCC 20542 Under Various Vegetable Oils Used as Sole and Supplementary Carbon Sources
TL;DR: In this paper, the effect of vegetable oils used as sole and supplementary carbon sources on the production of lovastatin by Aspergillus terreus ATCC 20542 and their biomass in submerged fermentation has been examined.
References
More filters
Book
Response Surface Methodology: Process and Product Optimization Using Designed Experiments
TL;DR: Using a practical approach, this book discusses two-level factorial and fractional factorial designs, several aspects of empirical modeling with regression techniques, focusing on response surface methodology, mixture experiments and robust design techniques.
Journal ArticleDOI
Modeling and optimization I: Usability of response surface methodology
Deniz Baş,Ismail Hakki Boyaci +1 more
TL;DR: This paper looked at some of the RSM articles published during the last few years to identify common mistakes made in the application and the limitations of RSM.
Journal ArticleDOI
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alfred W. Alberts,Julie S. Chen,G Kuron,V Hunt,Jesse W. Huff,Carl H. Hoffman,John W. Rothrock,Lopez Maria B,Henry Joshua,Elbert E. Harris,Arthur A. Patchett,R L Monaghan,S Currie,E Stapley,George Albers-Schonberg,Otto D. Hensens,J Hirshfield,Karst Hoogsteen,Jerrold M. Liesch,James P. Springer +19 more
TL;DR: It was shown that mevinolin was an orally active cholesterol-lowering agent in the dog and orally administered sodium mevinolinate was an active inhibitor of cholesterol synthesis in an acute assay.
Journal ArticleDOI
The biotechnological utilization of cheese whey: A review
TL;DR: Cheese-whey utilization has been the subject of much research as mentioned in this paper and the most representative applications of cheese whey being exploited and under research are briefly discussed in this paper.