Journal ArticleDOI
Vardenafil improves penile erection in type 2 diabetes mellitus patients with erectile dysfunction: role of tropomyosin.
José J. Zamorano-León,Carlos Olivier,Natalia de las Heras,Petra J. Mateos-Cáceres,Ricardo Brime Menéndez,Pablo Rodríguez-Sierra,Naihara Martín Palacios,Luis San José Manso,Javier Modrego,Antonio Segura,Carlos Macaya,Antonio J. López-Farré +11 more
Reads0
Chats0
TLDR
Vardenafil administration improved erectile functionality in controlled type 2 diabetes mellitus patients with ED, which was associated with reduction of circulating plasma β-tropomyosin levels and a possible new mechanism involved in ED.About:
This article is published in The Journal of Sexual Medicine.The article was published on 2013-12-01. It has received 6 citations till now. The article focuses on the topics: Vardenafil & cGMP-specific phosphodiesterase type 5.read more
Citations
More filters
Journal ArticleDOI
Erectile Dysfunction: AUA Guideline.
Arthur L. Burnett,Ajay Nehra,Rodney H. Breau,Daniel J. Culkin,Martha M. Faraday,Lawrence S. Hakim,Joel J. Heidelbaugh,Mohit Khera,Kevin T. McVary,Martin Miner,Christian J. Nelson,Hossein Sadeghi-Nejad,Allen D. Seftel,Alan W. Shindel +13 more
TL;DR: This document is designed to be used in conjunction with the associated treatment algorithm, and all patients should be informed of all treatment modalities that are not contraindicated, regardless of invasiveness or irreversibility, as potential first‐line treatments.
Journal ArticleDOI
Effect of Pectin on the Expression of Proteins Associated with Mitochondrial Biogenesis and Cell Senescence in HT29-Human Colorectal Adenocarcinoma Cells
José J. Zamorano-León,Sandra Ballesteros,Natalia de las Heras,Luis A. Álvarez-Sala,Mariano de la Serna-Soto,Khaoula Zekri-Nechar,Gala Freixer,Bibiana Calvo-Rico,Zhengguang Yang,José Manuel García-García,Vicente Lahera,Antonio J. López-Farré +11 more
TL;DR: It is concluded that pectin reduces the viability of human HT29 colon cancer cells, which is accompanied with a shift in the expression of proteins associated with mitochondrial dynamics towards mitochondrial fusion.
Journal ArticleDOI
BRCA2 gene mutations and coagulation-associated biomarkers
Pedro Pérez-Segura,José J. Zamorano-León,Daniel Acosta,Juana María Santos-Sancho,Javier Modrego,Trinidad Caldés,Miguel de la Hoya,Eduardo Díaz-Rubio,Isabel Díaz-Millán,Natalia de las Heras,Luis Alfonso Rico Zalba,Vicente Lahera,Olle Melander,Antonio López Farré +13 more
TL;DR: The presence of BRCA2 mutations is associated with increased plasma levels of thrombo-coagulating-related proteins, which are independent to breast cancer development.
Journal ArticleDOI
Therapeutic Potential of Phosphodiesterase Inhibitors for Endothelial Dysfunction- Related Diseases.
TL;DR: The effects of PDE inhibitors in CVD related to altered endothelial function, such as atherosclerosis, diabetes mellitus, arterial hypertension, stroke, aging and cirrhosis are discussed, increasing the evidence that these drugs are potential treatment strategies for vascular dysfunction and reinforcing their potential role in the pharmacotherapy of CVD.
References
More filters
Journal ArticleDOI
Integrins: Bidirectional, Allosteric Signaling Machines
TL;DR: Current structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways.
Journal ArticleDOI
Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation.
TL;DR: A unified working diagnostic tool for the metabolic syndrome that is convenient to use in clinical practice and that can be used world-wide so that data from different countries can be compared.
Journal ArticleDOI
Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function.
TL;DR: The EF domain possesses favorable statistical properties as a diagnostic tool, not only in distinguishing between men with and without erectile dysfunction, but also in classifying levels of ED severity.
Journal Article
European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force Of European and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of eight societies and by invited experts).
Guy De Backer,Guy De Backer,Ettore Ambrosioni,Knut Borch-Johnsen,Carlos Brotons,Renata Cifkova,Jean Dallongeville,Shah Ebrahim,Ole Faergeman,I. M. Graham,Giuseppe Mancia,Volkert Manger Cats,Kristina Orth-Gomér,Joep Perk,Kalevi Pyörälä,Jose L. Rodicio,Susana Sans,Vedat Sansoy,Udo Sechtem,Sigmund Silber,Troels Thomsen,David R. Wood +21 more
TL;DR: Preamble Guidelines aim to present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure and be helpful in everyday clinical decision-making.
Journal ArticleDOI
Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes
Nevila Hyka,Jean-Michel Dayer,Christine Modoux,Tadahiko Kohno,Carl K. Edwards,Pascale Roux-Lombard,Danielle Burger +6 more
TL;DR: Functional assays and flow cytometry analyses show that high-density lipoprotein (HDL)-associated apo A-I inhibits contact-mediated activation of monocytes by binding to stimulated T cells, thus inhibiting TNF-alpha and IL-1beta production at both protein and messenger RNA levels.