Journal ArticleDOI
Varicocele and hypogonadism.
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TLDR
It is demonstrated that microsurgical varicocelectomy improves testosterone levels in men with varicocele and low testosterone preoperatively and on testosterone level during and after surgery.Abstract:
Accumulating evidence suggests that varicocele, long associated with male infertility, is also a risk factor for low testosterone levels. The exact pathophysiology of the negative effects of varicocele on testicular function is not well understood, but theories include venous stasis, increased testicular temperature, oxidative stress, and resulting toxic environment. While prior studies report conflicting effects of non-microsurgical varicocelectomy on testosterone level, recent literature demonstrates that microsurgical varicocelectomy improves testosterone levels in men with varicocele and low testosterone preoperatively.read more
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Varicoceles: prevalence and pathogenesis in adult men
TL;DR: The prevalence ofvaricocele in adults, the anatomic features of varicocele, the leading theories as to how varicoCele can negatively affect fertility potential, and the current literature on the impact of varICOcele on testosterone production are discussed.
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The impact of coexisting sperm DNA fragmentation and seminal oxidative stress on the outcome of varicocelectomy in infertile patients: A prospective controlled study.
TL;DR: DFI% could be recommended as a prognostic test in infertile patients with varicocele to help decision-making as regards the necessity and the anticipated outcome of varicocelectomy in patients with infertility.
Journal ArticleDOI
Diagnostic and Management Approaches to Pediatric and Adolescent Varicocele: A Survey of Pediatric Urologists
TL;DR: Significant variation in diagnostic approaches, decision to treat, and operative approaches exists among pediatric urologists, and combined with a dearth of objective data, limits development of management guidelines.
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Microscopic varicocelectomy significantly decreases the sperm DNA fragmentation index in patients with infertility.
TL;DR: The data suggest that varicocelectomy can improve multiple semen parameters and sperm DNA damage in infertile men with varicocele and the patients with preoperative defects in those parameters showed greater improvement postoperatively.
References
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Journal ArticleDOI
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
TL;DR: Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
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Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
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Loss of fertility in men with varicocele.
TL;DR: Men with varicocele was palpable in 35% (352/1,001) of men with primary infertility and 81% (79/98) men with secondary infertility.
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Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique.
TL;DR: This minimally invasive, outpatient technique results in a significant decrease in the incidence of hydrocele formation, testicular artery injury and varicocele recurrence among 382 men available for followup examination from 6 months to 7 years postoperatively.
Journal ArticleDOI
Varicocele: a progressive or static lesion?
TL;DR: It is concluded that a varicocele in some men is a progressive and not a static lesion resulting in the loss of previously established fertility.