Journal ArticleDOI
Vascular Permeation of Platelet Factor 4 after Endothelial Injury
TLDR
This study demonstrates that factors carried by platelets can enter the vessel wall and that the movement of these platelet products into the vasculature is a short-lived, self-limiting process.Abstract:
Antibody to platelet factor 4 was used to demonstrate permeation of this factor into the blood vessel wall after endothelial injury in rabbits. The presence of platelet factor 4 antigen in the vessel wall after removal of the endothelium was shown by immunofluorescence 10 and 30 minutes after injury but not 240 minutes afterward. This study demonstrates that factors carried by platelets can enter the vessel wall and that the movement of these platelet products into the vasculature is a short-lived, self-limiting process.read more
Citations
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Journal ArticleDOI
Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia.
TL;DR: Intimal hyperplasia after balloon injury is a complex process involving platelets, growth factors, endothelial cells, smooth muscle cells, mechanical injury, wall shear stress, and probably other unknown factors.
Book ChapterDOI
The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation
J M Munro,R S Cotran +1 more
TL;DR: That Atherosclerosis has similarities to inflammation will be apparent from the considerations which follow, as will be the implications of these concepts to future work on the pathogenesis of atherosclerosis and its prevention and treatment.
Journal ArticleDOI
Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.
TL;DR: The high level of chemotactic activity of PDGF suggests that in addition to its role as a mitogen for smooth muscle cells and fibroblasts, PDGF may be involved in attracting inflammatory cells to sites of platelet release.
Journal ArticleDOI
George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.
TL;DR: In this lecture, a series of questions concerning the role played by each of the cells of the blood and of the artery wall as well as the role of cholesterol in atherosclerosis are raised.
Journal ArticleDOI
Vasoconstriction: a new activity for platelet-derived growth factor.
TL;DR: Observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.
References
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Journal ArticleDOI
Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process
TL;DR: The induction of DNA synthesis in quiescent BALB/c 3T3 cells can be resolved into at least two phases, controlled by different serum components: (i) competence, induced by the platelet-derived growth factor; and (ii) progression of competent cells into the cell cycle, mediated by factors in Platelet-poor plasma.
Journal ArticleDOI
Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate
R B Rutherford,R Ross +1 more
TL;DR: One of the principal mitogens for fibroblasts and for arterial smooth muscle cells in culture present in all blood sera thus far examined appears to be derived from platelet factor, which may relate to the proliferative response observed in atherogenesis in vivo.
Journal ArticleDOI
Amino acid sequence of human platelet factor 4
TL;DR: Human platelet factor 4, a protein that binds heparin, has been purified to apparent homogeneity and the complete amino acid sequence of the protein has been determined, demonstrating a highly negatively charged amino-terminal region.
Journal ArticleDOI
Studies of the Release from Human Platelets of the Growth Factor for Cultured Human Arterial Smooth Muscle Cells
TL;DR: The results suggest that PDGF, PF4, and βTG are localized in the platelet in granules different from either the dense bodies (that contain serotonin, ADP, ATP) or the acid hydrolase-containing granules, possibly in α-granules.
Journal ArticleDOI
Purification and binding properties of human platelet factor four.
Robert I. Handin,Howard J. Cohen +1 more
TL;DR: Evidence is presented that binding to aminoglycans occurs via ionic interactions between lysine residues on the protein and negatively charged groups on theAminoglycan and the degree of sulfation of the aminglycans correlated with the ability to displace [3H]heparin, and the conformation fo the carboxyl group of the uronic acid and the location of the sulfate Groups on the amino sugar influenced the affinity for the protein.