Journal ArticleDOI
The platelet-derived growth factor
Russell Ross,Arthur M. Vogel +1 more
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TLDR
It is likely that PDGF is released from platelets at sites of vascular damage and that it contributes toward the cell proliferation and connective tissue formation seen in healing wounds and in arteriosclerotic lesions.About:
This article is published in Cell.The article was published on 1978-06-01. It has received 659 citations till now. The article focuses on the topics: Blood serum & Platelet.read more
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The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal ArticleDOI
Early signals in the mitogenic response
TL;DR: Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts are integrated in a unified hypothesis for the regulation of fibroblast growth.
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The free radical theory of aging.
TL;DR: The free radical theory of aging postulates that aging changes are caused by free radical reactions, and data indicate that average life expectancy at birth may be increased by 5 or more years, by nutritious low caloric diets supplemented with one or more free radical reaction inhibitors.
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Bone substitutes in orthopaedic surgery: from basic science to clinical practice
Vincenzo Campana,Giuseppe Milano,Ernesto Damiano Pagano,Marta Barba,Claudia Cicione,G. Salonna,Wanda Lattanzi,Giandomenico Logroscino +7 more
TL;DR: The alternative available techniques used for bone fusion are reviewed and update, along with some hints on the advancements achieved through the experimental research in this field.
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Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation.
TL;DR: The role of vascular injury in the pathogenesis of spontaneous and accelerated atherosclerosis, and the resultant cellular pathophysiologic responses, specifically, lipid accumulation, platelet aggregation, thrombus formation and smooth muscle cell proliferation, are discussed.
References
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The pathogenesis of atherosclerosis (first of two parts).
Russell Ross,John A. Glomset +1 more
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Epidermal growth factor
TL;DR: The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
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Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
TL;DR: The isolation of the factor responsible for the earlier development of the incisors and eyelids is reported here, a heat-stable, nondialysable, antigenic protein, whose most distinctive chemical characteristic is the absence of phenylalanine and lysine.
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A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro
TL;DR: Much of the growth-promoting activity of dialyzed serum is directly or indirectly derived from platelets, which has important implications for the response of arteries to localized injury and provides a key to further understanding of the role of factors derived from blood serum in promoting cell proliferation in vitro.
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125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.
TL;DR: The data are consistent with a mechanism in which 125I-hEGF initially is bound to the cell surface and subsequently is internlized before degradation, and the binding capacity of these cells is restored by incubation in a serum-containing medium.