Journal ArticleDOI
Vasodilator therapy of heart failure. Has the promissory note been paid
TLDR
It is reported in the Journal that a single oral dose of prazosin could improve the altered hemodynamics of heart failure and it was suggested that "vasodilator therapy is emerging".Abstract:
IN 1977 Miller et al reported in the Journal that a single oral dose of prazosin could improve the altered hemodynamics of heart failure1 Among the desirable characteristics of this alpha-1-adrenread more
Citations
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Journal ArticleDOI
A simple method for noninvasive estimation of pulmonary vascular resistance
Amr E. Abbas,F. David Fortuin,Nelson B. Schiller,Christopher P. Appleton,Carlos A. Moreno,Steven J. Lester +5 more
TL;DR: Whether the ratio of peak tricuspid regurgitant velocity to the right ventricular outflow tract time-velocity integral obtained by Doppler echocardiography (TRV/TVI(RVOT)) provides a clinically reliable method to determine pulmonary vascular resistance (PVR) is tested.
Journal ArticleDOI
Haemodynamic effects of atrial peptide infusion in heart failure
TL;DR: The effect of a synthetic analogue of atrial natriuretic peptide (Ileu-ANP) on haemodynamic, hormonal, and electrolyte excretion indices was studied in patients with chronic congestive heart failure.
Journal ArticleDOI
ACE inhibitors--a cornerstone of the treatment of heart failure.
TL;DR: For many years digitalis and diuretic agents have been the cornerstones of pharmacologic treatment for patients with heart failure, but a potential therapeutic role for vasodilators was first suggested in 2012.
Journal ArticleDOI
Effect of vasodilators on survival in chronic congestive heart failure
Curt D. Furberg,Salim Yusuf +1 more
TL;DR: Although advances in the medical treatment of systemic hypertension and myocardial infarction and the surgical treatment of congenital and valvular heart disease and multivessel coronary artery disease can prolong survival, CHF ultimately develops in many patients in later life.
Journal ArticleDOI
Oral amrinone for the treatment of chronic congestive heart failure: Results of a multicenter randomized double-blind and placebo-controlled withdrawal study
TL;DR: It is suggested that amrinone, in the dosages tested, does not importantly improve cardiac function beyond that provided by standard treatment with digoxin, diuretic drugs and vasodilators.
References
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Journal ArticleDOI
Sustained Effectiveness of Converting-Enzyme Inhibition in Patients with Severe Congestive Heart Failure
Victor J. Dzau,Wilson S. Colucci,Gordon H. Williams,Gregory D. Curfman,Leonard G. Meggs,Norman K. Hollenberg +5 more
TL;DR: It is concluded that captopril reduces afterload in advanced congestive heart failure and induces sustained improvements in clinical status and renal function.
Journal ArticleDOI
Evaluation of a New Bipyridine Inotropic Agent — Milrinone — in Patients with Severe Congestive Heart Failure
Donald S. Baim,Donald S. Baim,A V McDowell,A V McDowell,J Cherniles,J Cherniles,E S Monrad,E S Monrad,John Parker,John Parker,J Edelson,J Edelson,Eugene Braunwald,Eugene Braunwald,William Grossman,William Grossman +15 more
TL;DR: It is concluded that milrinone shows promise for the longterm treatment of congestive heart failure and does not cause fever, thrombocytopenia, gastrointestinal intolerance, or aggravation of ventricular ectopy.
Journal ArticleDOI
Sustained reduction of cardiac impedance and preload in congestive heart failure with the antihypertensive vasodilator prazosin.
TL;DR: Prazosin benefits severe congestive heart failure by inducing a sustained fall of both cardiac preload and impedance, and reduces vascular resistance and venous tone in both forearms.
Journal ArticleDOI
Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat
TL;DR: Chronic therapy with captopril produced a marked regression of cardiac hypertrophy and prevented the deterioration of cardiac performance in SHR with long-standing hypertension.
Journal ArticleDOI
Acute regional circulatory and renal hemodynamic effects of converting-enzyme inhibition in patients with congestive heart failure.
Mark A. Creager,Jonathan L. Halperin,David B. Bernard,David P. Faxon,Caroline D. Melidossian,Haralambos Gavras,Thomas J. Ryan +6 more
TL;DR: It is concluded that converting-enzyme inhibition reverses renal vasoconstriction in congestive heart failure and redistributes regional blood flow through improved renal plasma flow, reduction in filtration fraction, suppression of hyperaldosteronism, and lowering of circulatory catecholamine concentrations.
Related Papers (5)
Vasodilator therapy of cardiac failure: (first of two parts).
Jay N. Cohn,Joseph A. Franciosa +1 more
Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study.
Jay N. Cohn,Donald G. Archibald,Susan Ziesche,Joseph A. Franciosa,W. Eugene Harston,Felix E. Tristani,W. Bruce Dunkman,William R. Jacobs,Gary S. Francis,Kathleen H. Flohr,Steven Goldman,Frederick R. Cobb,Pravin M. Shah,Robert S. Saunders,Ross D. Fletcher,Henry S. Loeb,V. Hughes,Bonnie J. Baker +17 more