Journal ArticleDOI
Vibrational spectra of captopril (SQ 14,225: 1-(D-3-mercapto-2-methylpropionyl)-L-proline) and the synthesis of the 1:1 coordination compound of captopril with Zn(II) and its characterization by vibrational spectra
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In this article, the infrared and Raman spectra of captopril (SQ 14,225) were published for the first time and their tentative assignment proposed, showing coordination of the drug through both carboxylate oxygens, carbonyl oxygen and through sulphur.About:
This article is published in Inorganica Chimica Acta.The article was published on 1987-08-01. It has received 15 citations till now. The article focuses on the topics: Coordination complex.read more
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Biological aspects of new organotin(IV) compounds of 3-maleimidopropionic acid
TL;DR: The triorganotin(IV) complexes were comparatively less toxic than the diorganotin(II) complexes and the organotin( IV) moieties establish chemical bonding with the ligand through carboxylic oxygen atom.
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Copper(II) interaction and complexation with 1-[2(S)-3-mercapto-3-methylpropionyl]-L-proline (captopril)
TL;DR: In this paper, the redox processes between copper and captopril in a molar ratio 1:2 were studied using spectral (UV-Vis, IR), magnetochemical, EPR, DTA, and TGA methods.
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Characterization of diorganotin(IV) complexes with captopril. The first crystallographically authenticated metal complex of this anti-hypertensive agent.
Hajnalka Jankovics,Claudio Pettinari,Fabio Marchetti,Erzsébet Kamu,László Nagy,Sergei I. Troyanov,Lorenzo Pellerito +6 more
TL;DR: The FTIR and Raman spectra demonstrated that the organotin(IV) moieties interact with the [S] atom of the ligand, while the other coordination sites are the carboxylate and the amide -CO groups.
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Free radical scavenging and copper chelation: a potentially beneficial action of captopril.
TL;DR: Investigation of the behaviour of Captopril towards radiation-induced radicals in the absence and in the presence of copper(II) ions suggests that CpSH may potentially inhibit oxidative damage both through free radical scavenging and metal chelation.
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Synthesis and characterization of a cobalt(III) complex with 1-(d-3-mercapto-2-methylpropionyl)-l-proline
TL;DR: The reaction of CoCl2 with 1-3-mercapto-2-methylpropionyl)-L-proline (L or captopril) yields a new nanocrystalline complex with general formula [CoL2(OH)]2, which has been characterised with infrared (IR) and ultra-violet visible (UV-vis) spectroscopies, magnetic measurements, X-ray photoelectron spectroscopy (XPS), and wide angle X
References
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Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination
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Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents
TL;DR: A hypothetical model of the active site of angiotensin-converting enzyme, based on known chemical and kinetic properties of the enzyme, has enabled a new class of potent and specific inhibitors, carboxyalkanoyl and mercaptoalkanoysl derivatives of proline, to be designed.
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Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids.
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Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy.
TL;DR: Captopril must be considered an exciting addition to the therapeutic armamentarium; it, and pharmacologically related compounds of the future, will continue to generate much interest as their final place in therapy becomes better defined through additional well designed studies and wider clinical experience.
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The infra-red absorption bands associated with the COOH and COOD groups in dimeric carboxylic acid—II: The region from 3700 to 1500 cm−1
S. Bratož,D. Hadži,N. Sheppard +2 more
TL;DR: In this article, the authors investigated the infra-red spectra of a number of dimeric carboxylic acids and their deutero (COOD) analogues in the region of 3700 to 1500 cm−1.