Journal ArticleDOI
Visceral leishmaniasis after orthotopic liver transplantation: impact of persistent splenomegaly
TLDR
Visceral leishmaniasis was observed in a 50-year-old female liver transplant recipient 1 year following transplantation and the patient remains without signs of active infection 1 year after successful therapy.Abstract:
Visceral leishmaniasis was observed in a 50-year-old female liver transplant recipient 1 year following transplantation. Signs of active infection were low-grade fever, pancytopenia, persistent splenomegaly, positive cultures for leishmania in liver and bone marrow biopsy specimens, and newly positive leishmania serology. Following sequential therapy with pentavalent antimony and amphotericin B, blood values improved massively, bone marrow cultures became negative, and leishmania serology decreased. Secondary prophylaxis with fluconazole was instituted and the patient remains without signs of active infection 1 year after successful therapy.read more
Citations
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Journal ArticleDOI
Leishmaniasis among organ transplant recipients
TL;DR: In this paper, the authors used liposomal amphotericin B (LAPB) as the first-line therapy in transplant patients with viscerotropic leishmaniasis.
Journal ArticleDOI
Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation
Pilar Martín-Dávila,Jesús Fortún,Rogelio López-Vélez,Francesca F. Norman,M. Montes de Oca,P. Zamarrón,M. I. González,A. Moreno,T. Pumarola,G. Garrido,A. Candela,Santiago Moreno +11 more
TL;DR: Recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients are elaborated.
Journal ArticleDOI
Parasitic Infections in Solid Organ Transplantation
TL;DR: Abbreviations: BAL, bronchoalveolar lavage; CDC, Centers for Disease Control and Prevention; CMV, cytomegalovirus; CNS, central nervous system; CSF, cerebral spinal fluid; DD, disseminated disease; DS, double strength; EIA, Enzyme Immunoassay; ELISA, En enzyme-linked immunosorbent assay; FDA, Food and Drug Administration; FIA, Fluorescence ImmunoASSay.
Journal ArticleDOI
Visceral leishmaniasis in organ transplant recipients: 11 new cases and a review of the literature
Didier Basset,Françoise Faraut,Pierre Marty,Jacques Dereure,Eric Rosenthal,Charles Mary,Francine Pratlong,Laurence Lachaud,Patrick Bastien,Jean-Pierre Dedet +9 more
TL;DR: VL was most commonly associated with renal transplantation and most patients were from Southern European countries, and leucopoenia and anaemia were the most frequent haematological disorders.
Journal ArticleDOI
Visceral leishmaniasis (Kala-Azar) in transplant recipients: case report and review.
Juan Berenguer,Francisco Gómez-Campderá,Belén Padilla,Marisa Rodriguez-Ferrero,F. Anaya,Santiago Moreno,Fernando Valderrábano +6 more
TL;DR: In endemic areas, visceral leishmaniasis may complicate the clinical course of organ transplantation and can have fatal consequences, particularly when untreated.
References
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Journal ArticleDOI
Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma.
Roberto Badaró,Ernesto Falcoff,F. Badaro,Edgar M. Carvalho,Diana Pedral-Sampaio,Aldina Barral,José Sérgio Fonseca de Carvalho,Manoel Barral-Netto,Maud Brandely,Luciana Silva,José Carlos Bina,R. Teixeira,Rebeca Falcoff,Heonir Rocha,John L. Ho,Warren D. Johnson +15 more
TL;DR: It is concluded that the combination of interferon gamma and pentavalent antimony is effective in treating seriously ill patients with refractory or previously untreated visceral leishmaniasis.
Journal ArticleDOI
Incidence, distribution, and outcome of episodes of infection in 100 orthotopic liver transplantations.
Carlos V. Paya,Paul E. Hermans,John A. Washington,Thomas F. Smith,John P. Anhalt,Russell H. Wiesner,Ruud A.F. Krom +6 more
TL;DR: It is suggested that the use of selective bowel decontamination may be associated with a relatively lower incidence of gram-negative aerobic bacterial infections after liver transplantation.
Journal ArticleDOI
Visceral leishmaniasis in immunocompromised hosts
Manuel L. Fernández-Guerrero,JoséM. Aguado,Buzón L,Carlos Barros,Carlos Montalbán,Teodoro Martín,Emilio Bouza +6 more
TL;DR: In a series of 10 patients with visceral leishmaniasis complicating renal transplantation, hematologic neoplasms, systemic lupus erythematosus, or infection with human immunodeficiency virus, typical hallmarks of kalaazar such as enlargement of spleen or hyperglobulinemia were absent.
Journal ArticleDOI
Visceral leishmaniasis in patients infected with human immunodeficiency virus (HIV).
Juan Berenguer,Santiago Moreno,Emilia Cercenado,J. C. L. Bernaldo de Quirós,A. Garcia De La Fuente,Emilio Bouza +5 more
TL;DR: Visceral leishmaniasis developed before full-blown acquired immunodeficiency syndrome (AIDS) in seven patients and at the same time as or after AIDS in the other two patients.
Journal ArticleDOI
Effect of IFN-γ on the immune response in vivo and on gene expression in vitro
TL;DR: It is found that for several antigens, administration of IFN-γ to mice leads to two- to five-fold enhancement of antibody formation provided that the IFn-γ and antigen are administered together.