Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases.
Alcides Chaux,Pheroze Tamboli,Alberto G. Ayala,Fernando Augusto Soares,Ingrid Rodriguez,José E. Barreto,Antonio L. Cubilla +6 more
TLDR
Warty-basaloid carcinomas are morphologically distinctive human papillomavirus-related penile neoplasms that are biologically more aggressive than typical warty carcinoma from which they should be distinguished.About:
This article is published in Modern Pathology.The article was published on 2010-01-01 and is currently open access. It has received 49 citations till now. The article focuses on the topics: Penile Intraepithelial Neoplasia & Penile Neoplasm.read more
Citations
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The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
TL;DR: This review summarizes the most significant differences between the newly published classification of urogenital tumours and the prior version for renal, penile, and testicular tumours.
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Value of p16INK4a in the Pathology of Invasive Penile Squamous Cell Carcinomas: A Report of 202 Cases
Antonio L. Cubilla,Belen Lloveras,Maria Alejo,Omar Clavero,Alcides Chaux,Elena Kasamatsu,Núria Monfulleda,Sara Tous,Laia Alemany,Joellen Klaustermeier,Nubia Muñoz,Wim Quint,Silvia de Sanjosé,F. X. Bosch +13 more
TL;DR: p16INK4a overexpression was found to be a reliable marker for HR-HPV and a helpful tool in the differential diagnosis of low-grade verruciform and high-grade solid penile tumors and this observation may have diagnostic and prognostic implications.
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Two major pathways of penile carcinogenesis: HPV-induced penile cancers overexpress p16ink4a, HPV-negative cancers associated with dermatoses express p53, but lack p16ink4a overexpression
TL;DR: In this article, the authors classified penile lesions into HPV-induced or HPV-negative via immunohistochemical demonstration of p16 ink4a overexpression, a surrogate marker for transforming HPV-high-risk infections, and p53 expression in the absence of P16 Ink4a over-expression.
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Advances in the pathology of penile carcinomas.
Alcides Chaux,Antonio L. Cubilla +1 more
TL;DR: The role of pathologic features in the prognosis ofPenile cancer, the characteristics of penile precursor lesions, and the use of immunohistochemistry for the diagnosis of invasive and precursor lesions are discussed.
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Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants.
TL;DR: A review of cutaneous squamous cell carcinoma variants, emphasizing diagnostic pitfalls, immuhistochemical findings and prognostic significance, is included in the eighth edition of the American Joint Committee on Cancer Staging Manual.
References
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Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis.
Mark A. Rubin,Bernard Kleter,Ming Zhou,Gustavo Ayala,Antonio L. Cubilla,Wim Quint,Edyta C. Pirog +6 more
TL;DR: In this paper, the authors evaluated the prevalence of human papillomavirus (HPV) DNA in different histological subtypes of penile carcinoma, dysplasia, and condyloma using a novel sensitive SPF10 HPV polymerase chain reaction assay and a novel genotyping line probe assay, allowing simultaneous identification of 25 different HPV types.
Journal Article
Variants of Squamous Cell Carcinoma of the Anal Canal and Perianal Skin and Their Relation to Human Papillomaviruses
Morten Frisch,C. Fenger,A. J. C. Van Den Brule,Per Soelberg Sørensen,C. J. L. M. Meijer,J. M. M. Walboomers,Hans-Olov Adami,Mads Melbye,Bengt Glimelius +8 more
TL;DR: In both women and men, anal canal cancers contained hrHPVs clearly more often than did perianal skin cancers, and increasing hrHPV positivity was seen with higher localization in the anal canal.
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Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways.
I.A.M. van der Avoort,Hebste Shirango,B. M. Hoevenaars,Johanna M. M. Grefte,J.A. de Hullu,P.C.M. de Wilde,Johan Bulten,Willem J. G. Melchers,L.F.A.G. Massuger +8 more
TL;DR: The results provide further evidence that vulvar squamous cell carcinoma is a multifactorial disease that develops from two different pathways, an HPV-dependent pathway with a remarkable resemblance to CIN lesions and cervical carcinoma and a HPV-independent pathway in which differentiated VIN III lesions that are hr-HPV-negative may be precursors.
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Preferential Association of Human Papillomavirus With High-Grade Histologic Variants of Penile-Invasive Squamous Cell Carcinoma
TL;DR: The low frequency of HPV in penile SCC implies that only a small proportion of these cancers arise from HPV-associated penile SIL, and HPV DNA sequences tended to be associated with higher grade and more aggressive tumor localized to the glans penis.