Journal ArticleDOI
Well-differentiated pancreatic tumor/carcinoma: Insulinoma
Wouter W. de Herder,Bruno Niederle,Jean-Yves Scoazec,Stanislas Pauwels,Günter Klöppel,Massimo Falconi,Dik J. Kwekkeboom,Kjell Öberg,Barbro Eriksson,Bertram Wiedenmann,Guido Rindi,Dermot O'Toole,Diego Ferone +12 more
TLDR
a Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands; b Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria;Abstract:
a Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands; b Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria; c Hospices Civils de Lyon, Hopital Edouard-Herriot Service Central d‘Anatomie et Cytologie Pathologiques, Lyon , France; d Centre de Medecine Nucleaire, Universite Catholique de Louvain, Brussels , Belgium; e Department of Pathology, University of Kiel, Kiel , Germany; f B Unit of Surgery, Department of Surgery, University of Verona, Verona , Italy; g Department of Nuclear Medicine, Erasmus MC, Rotterdam , The Netherlands; h Department of Endocrine Oncology, University Hospital, Uppsala , Sweden; i Department of Internal Medicine, Division of Hepatology and Gastroenterology, Interdisciplinary Center of Metabolism and Endocrinology, Charite, Campus Virchow Hospital, University for Medicine Berlin, Berlin , Germany; j Service de Gastroenterologie-Pancreatologie, Pole des Maladies de l‘Appareil Digestif, Hopital Beaujon, Clichy , France; k Department of Pathology and Laboratory Medicine, Universita degli Studi, Parma, Italy; l Department of Endocrinology, Genoa University, Genoa , Italyread more
Citations
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Journal ArticleDOI
TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system
Guido Rindi,Günter Klöppel,Anne Couvelard,P. Komminoth,Meike Körner,José Manuel Lopes,Anne Marie McNicol,Ola Nilsson,Aurel Perren,Aldo Scarpa,J.-Y. Scoazec,Bertram Wiedenmann +11 more
TL;DR: The proposed tumor–node–metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow the previous proposal for foregut tumors.
Journal ArticleDOI
ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary.
Marianne Pavel,Eric Baudin,Anne Couvelard,Eric P. Krenning,Kjell Öberg,Thomas Steinmüller,Martin Anlauf,Bertram Wiedenmann,Ramon Salazar +8 more
TL;DR: ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, MidGut, Hind gut, and Unknown Primary
Journal ArticleDOI
Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors.
David C. Metz,Robert T. Jensen +1 more
TL;DR: A number of recent advances regarding the molecular pathology, diagnosis, localization, and management of PETs are addressed including discussion of peptide-receptor radionuclide therapy and other novel antitumor approaches and a discussion of future directions and unsettled problems in the field.
Book ChapterDOI
Pathology and Genetics
TL;DR: Local aggressiveness consists in the invasion of contiguous structures and organs (spleen, stomach, left adrenal gland, colon, and peritoneum), whereas distant metastases can occur in liver, lungs, adrenals, kidneys, bones, brain, and skin.
Journal ArticleDOI
ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes.
Robert T. Jensen,Guillaume Cadiot,Maria Luisa Brandi,Wouter W. de Herder,Gregory Kaltsas,Paul Komminoth,Jean-Yves Scoazec,Alain Sauvanet,Reza Kianmanesh +8 more
TL;DR: The two most common functional p-NETs (gastrinomas, insulinomas) are considered separately, whereas the other well-described and possible rarefunctional p- NETs are considered together as a group called rare functional rFTs (RFTs).
References
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Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients
E. P. Krenning,Dirk Jan Kwekkeboom,Willem H. Bakker,W. A. P. Breeman,P. P. M. Kooij,H. Y. Oei,M. van Hagen,P. T. E. Postema,M. De Jong,Jean Claude Reubi,Theo J. Visser,Ambroos E.M. Reijs,Leo J Hofland,Jan W. Koper,S. W. J. Lamberts +14 more
TL;DR: The successful application of radiolabelled octreotide in scintigraphy indicates the possible usefulness of other radiolABelled peptides, either native peptides or derivatives of these, in, for example, nuclear oncology.
Journal Article
Drug therapy : octreotide
Journal ArticleDOI
Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate in Patients With Endocrine Gastroenteropancreatic Tumors
Dik J. Kwekkeboom,Jaap J.M. Teunissen,Willem H. Bakker,P. P. M. Kooij,Wouter W. de Herder,Richard A Feelders,Casper H.J. van Eijck,Jan-Paul Esser,Boen L. Kam,Eric P. Krenning +9 more
TL;DR: Treatment with 177Lu-octreotate results in tumor remission in a high percentage of patients with GEP tumors, and results are better in patients with a limited tumor load.
Journal ArticleDOI
Whole-Body 11C-5-Hydroxytryptophan Positron Emission Tomography as a Universal Imaging Technique for Neuroendocrine Tumors : Comparison with Somatostatin Receptor Scintigraphy and Computed Tomography
Håkan Örlefors,Anders Sundin,Ulrike Garske,Claes Juhlin,Kjell Öberg,Britt Skogseid,Bengt Långström,Mats Bergström,Barbro Eriksson +8 more
TL;DR: It is shown that WB-(11)C-5-HTP-PET is sensitive in imaging small NET lesions, such as primary tumors, and can in a majority of cases image significantly more tumor lesions than SRS and CT.
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