Journal ArticleDOI
Where's the high-grade cervical neoplasia? The importance of minimally abnormal Papanicolaou diagnoses
TLDR
Recognition of the importance of equivocal and mild Papanicolaou test abnormalities in the subsequent diagnosis of high-grade cervical neoplasia emphasizes the need for accurate and cost-effective triage of the large population of women with minimally abnormal PapanIColaou diagnoses.About:
This article is published in Obstetrics & Gynecology.The article was published on 1998-06-01. It has received 271 citations till now. The article focuses on the topics: Papanicolaou Test & Bethesda system.read more
Citations
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Journal ArticleDOI
Human papillomavirus and cervical cancer
TL;DR: The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology, and can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings.
Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women with Cervical Cytological Abnormalities.
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Human Papillomavirus Testing in the Prevention of Cervical Cancer
Mark Schiffman,Nicolas Wentzensen,Sholom Wacholder,Walter Kinney,Julia C. Gage,Philip E. Castle +5 more
TL;DR: The natural history and cervical carcinogenicity of HPV is summarized, the promise and uncertainties of currently available screening methods are discussed, and the greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment.
Journal ArticleDOI
Identifying Women With Cervical Neoplasia: Using Human Papillomavirus DNA Testing for Equivocal Papanicolaou Results
M. Michele Manos,Walter Kinney,Leo B. Hurley,Mark E. Sherman,Jen Shieh-Ngai,Robert J. Kurman,Janice E. Ransley,Barbara Fetterman,James S. Hartinger,Karen M. McIntosh,Gene F. Pawlick,Robert A. Hiatt +11 more
TL;DR: Whether human papillomavirus DNA testing of residual material from liquid-based Pap tests and referral of cases found to be HPV-positive directly to colposcopy could provide sensitive detection of underlying HSILs in women with ASCUS Pap results, compared with repeat Pap testing is investigated.
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Evidence for Frequent Regression of Cervical Intraepithelial Neoplasia-Grade 2
TL;DR: There was evidence that approximately 40% of undiagnosed Cin 2 will regress over 2 years, but CIN 2 caused by HPV-16 may be less likely to regress than CIN2 caused by other high-risk–HPV genotypes.
References
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Journal ArticleDOI
Human papillomavirus testing by hybrid capture appears to be useful in triaging women with a cytologic diagnosis of atypical squamous cells of undetermined significance.
J. Thomas Cox,Attila T. Lorincz,Mark Schiffman,Mark E. Sherman,Allison Cullen,Robert J. Kurman +5 more
TL;DR: Testing for human papillomavirus deoxyribonucleic acid with hybrid capture appears to offer an effective means by which patients whose cervical Papanicolaou smears have been read as atypical squamous cells of undetermined significance could be triaged for colposcopy.
Journal ArticleDOI
Human papillomavirus testing by hybrid capture appears to be useful in triaging women with a cytologic of diagnosis of atypical squamous cells of unde termined significance
TL;DR: Testing for human papillomavirus deoxyribonucleic acid with hybrid capture appears to offer an effective means by which patients whose cervical Papanicolaou smears have been read as atypical squamous cells of undetermined significance could be triaged for colposcopy.
Journal ArticleDOI
Comparison of management algorithms for the evaluation of women with low-grade cytologic abnormalities
TL;DR: A repeat Papanicolaou smear combined with a HPV DNA test is a sensitive alternative to colposcopic evaluation for the detection of CIN in women referred for a previous low-grade abnormal PAP smear, but because of the low specificity, it results in only modest cost reductions compared to the more standard triage of performing colposcopy at the first visit.
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Atypical squamous cells of undetermined significance: interlaboratory comparison and quality assurance monitors.
TL;DR: Interlaboratory comparison and quality assurance methods for evaluating the rate and outcome of ASCUS serve to validate laboratory criteria and consequent clinical follow‐up and the ratio ASCUS/SIL may serve as a useful laboratory monitor.