Journal ArticleDOI
Wide variation in risk of wound infection following clean neurosurgery. Implications for perioperative antibiotic prophylaxis.
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TLDR
It is most feasible to demonstrate the potential efficacy of perioperative antibiotics in clean neurosurgical procedures with the greatest risk of postoperative wound infection and the potential benefit from such prophylaxis would be greatest for patients undergoing high-risk operations.Abstract:
The authors have prospectively examined the occurrence of postoperative wound infection following clean neurosurgery in 936 patients. Fewer than 1% received perioperative antibiotic prophylaxis. The overall rate of deep wound infection was 2.6%; no deaths were directly attributable to these infections. Deep wound infections occurred significantly more frequently following craniotomy (4.3%) than following spinal (0.9%) or other clean neurosurgery. Among craniotomies, the deep wound infection rate varied significantly from 11% following repeat operations for recurrent gliomas to 2.5% following non-tumor surgery. Risk of deep wound infection varied more than 11-fold depending on the type of clean neurosurgical operation. It is most feasible to demonstrate the potential efficacy of perioperative antibiotics in clean neurosurgical procedures with the greatest risk of postoperative wound infection. The potential benefit from such prophylaxis would be greatest for patients undergoing these high-risk operations.read more
Citations
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Risk factors for surgical site infection in spinal surgery
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Incidence, prevalence, and analysis of risk factors for surgical site infection following adult spinal surgery
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Shunt implantation: reducing the incidence of shunt infection.
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TL;DR: The authors consider the effects of the following factors on the rate of infection: length of preoperative stay, preparation of the patient for surgery, identification of patients at risk, surgical technique and choice of procedure, and acquainting staff with statistics of wound infection rates.
Journal ArticleDOI
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Peter J. E. Cruse,Rosemary Foord +1 more
TL;DR: Analysis of surgical wounds showed a reduction in the rate of infection in those using a hexachlorophene wash before operation and those whose operation site was not shaved, while no reduction or increase was observed when plastic skin drapes were used or when different hand-scrub preparations were used.
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