Journal ArticleDOI
Work-related eye injuries treated in hospital emergency departments in the US.
TLDR
The findings of this study underscore the need for use of appropriate eye protection and implementation, and enforcement of eye protection policies in the workplace to prevent work-related eye injuries.Citations
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Journal ArticleDOI
Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury
Joo Youn Oh,Gavin W. Roddy,Hosoon Choi,Ryang Hwa Lee,Joni Ylostalo,Robert H. Rosa,Darwin J. Prockop +6 more
TL;DR: The data indicated that TSG-6, a therapeutic protein produced by MSCs in response to injury signals, can protect the corneal surface from the excessive inflammatory response following injury.
Journal ArticleDOI
Differentiation of Human Limbal-Derived Induced Pluripotent Stem Cells Into Limbal-Like Epithelium
Dhruv Sareen,Mehrnoosh Saghizadeh,Loren Ornelas,Michael Winkler,Kavita Narwani,Anais Sahabian,Vincent Funari,Jie Tang,Lindsay Spurka,Vasu Punj,Ezra Maguen,Yaron S. Rabinowitz,Clive N. Svendsen,Alexander V. Ljubimov +13 more
TL;DR: The purpose of this study was to generate human iPSCs and direct them to limbal differentiation by maintaining them on natural substrata mimicking the native LESC niche, including feederless denuded human amniotic membrane and de‐epithelialized corneas.
Journal ArticleDOI
An update on chemical eye burns.
TL;DR: It is increasingly important to consider tertiary referral for patients with limbal stem cell failure or vision-limiting corneal scarring, and the evolution of treatment strategies has revolutionised the visual and cosmetic outcomes in chronic phases of disease.
Journal ArticleDOI
Safety and efficacy of topical infliximab in a mouse model of ocular surface scarring.
TL;DR: It is suggested that topical application of infliximab may be a useful treatment in ocular caustications by reducing corneal perforation, opacity index, phimosis, leukocyte infiltration, and fibrosis in the eyelids.
Journal ArticleDOI
A Simple Alkaline Method for Decellularizing Human Amniotic Membrane for Cell Culture
Mehrnoosh Saghizadeh,Michael Winkler,Andrei A. Kramerov,David M. Hemmati,David M. Hemmati,Chantelle A. Ghiam,Chantelle A. Ghiam,Slobodan D. Dimitrijevich,Dhruv Sareen,Loren Ornelas,Homayon Ghiasi,William J. Brunken,Ezra Maguen,Yaron S. Rabinowitz,Clive N. Svendsen,Clive N. Svendsen,Katerina Jirsova,Alexander V. Ljubimov +17 more
TL;DR: NaOH-denuded amniotic membrane supported growth of human limbal epithelial cells, immortalized corneal epithelium cells, and induced pluripotent stem cells and showed excellent preservation of immunoreactivity for major basement membrane components.
References
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Journal ArticleDOI
The epidemiology of serious eye injuries from the United States Eye Injury Registry.
D. R. May,Ferenc Kuhn,Robert Morris,Witherspoon Cd,Ronald P. Danis,G. P. Matthews,LoRetta Mann +6 more
TL;DR: It appears that glasses, including prescription glasses and even non-prescription sunglasses, can offer measurable protection which results in a lower incidence of severe eye injuries to those wearing glasses.
Journal ArticleDOI
Penetration eye injuries in the workplace. The National Eye Trauma System Registry.
TL;DR: National Eye Trauma System Registry data are useful to identify strategies to prevent occupational eye injuries such as wider use of safety glasses and improvement in engineering controls.
Journal ArticleDOI
Non-fatal occupational injuries and illnesses treated in hospital emergency departments in the United States.
TL;DR: Emergency department surveillance is particularly amenable to capture of young worker injuries and provides a wealth of injury details to guide prevention efforts—efforts that will likely reduce occupational injuries as these workers age.
Journal ArticleDOI
Eye Trauma: The Neglected Disorder
TL;DR: Injury is second only to cataract and strabismus as the leading cause for hospitalization and with the increasing use of outpatient surgery, injury will be even more important as an indication for hospitalizations in the future.
Journal ArticleDOI
Airbags and eye injuries: epidemiology, spectrum of injury, and analysis of risk factors.
TL;DR: awareness of the spectrum of airbag-associated ocular trauma will help physicians recognize these problems early and optimize their management, and data derived from analyses of these injuries will be critical to the development of safer, more effective devices.