Journal ArticleDOI
Xenotransplantation literature update, November-December 2012.
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TLDR
It is necessary to select patients suitable for xenotransplantation based on prior history and once they provide informed consent for surgery to assess the risks and benefits to minimize the number of adverse events.Abstract:
Schneider MKJ, Seebach JD. Xenotransplantation literature update, November–December 2012. Xenotransplantation 2013: 20: 36–38. © 2013 John Wiley & Sons A/S. Mårten K.J. Schneider and J€org D. Seebach Laboratory of Vascular Immunology, Division of Internal Medicine, University Hospital Zurich, Zurich, Switzerland, Service of Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty, Geneva, Switzerlandread more
References
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Journal ArticleDOI
Clinical Islet Xenotransplantation How Close Are We
Dirk J. van der Windt,Rita Bottino,Goutham Kumar,Martin Wijkstrom,Hidetaka Hara,Mohamed Ezzelarab,Burcin Ekser,Carol Phelps,Noriko Murase,Anna Casu,David Ayares,Fadi G. Lakkis,Massimo Trucco,David K. C. Cooper +13 more
TL;DR: Recent progress in preclinical models of pig islet xenotransplantation is reviewed and the remaining challenges that need to be addressed are discussed before the application of this form of therapy can be established in patients with T1D.
Journal ArticleDOI
Expression of porcine endogenous retroviruses (PERV) in different organs of a pig
TL;DR: A systematic analysis of PERV expression in different organs of a miniature pig using in parallel quantitative real-time RT-PCR, Western blot analysis, and immunohistochemistry finds a high expression of the viral full-length and spliced mRNA and proteins in lymphoid organs.
Journal ArticleDOI
Generation and characterization of human heme oxygenase-1 transgenic pigs.
Hye Jung Yeom,Ok Jae Koo,Jaeseok Yang,Jaeseok Yang,Bumrae Cho,Jong Ik Hwang,Sol Ji Park,Sunghoon Hurh,Hwajung Kim,Eun Mi Lee,Han Ro,Jung Taek Kang,Su Jin Kim,Jae Kyung Won,Philip J. O'Connell,Hyunil Kim,Charles D. Surh,Byeong Chun Lee,Curie Ahn +18 more
TL;DR: It is suggested that transgenic expression of human heme oxygenase-1 can protect xenografts when exposed to oxidative stresses, especially from ischemia/reperfusion injury, and/or acute rejection mediated by cytokines.
Journal ArticleDOI
Early Islet Damage after Direct Exposure of Pig Islets to Blood: Has Humoral Immunity Been Underestimated?:
Dirk J. van der Windt,Dirk J. van der Windt,Marco Marigliano,Jing He,Tatyana V. Votyakova,Gabriel J. Echeverri,Burcin Ekser,David Ayares,Fadi G. Lakkis,David K. C. Cooper,Massimo Trucco,Rita Bottino +11 more
TL;DR: A simplified in vitro model in which islets were exposed to blood in different clinically relevant but increasingly challenging, autologous, allogeneic, and xenogeneic combinations resulted in substantial islet injury after exposure of porcine islets to human blood.
Journal ArticleDOI
Xenotransplantation of islets enclosed in agarose microcapsule carrying soluble complement receptor 1.
Nguyen Minh Luan,Hiroo Iwata +1 more
TL;DR: In conclusion, sCR1 immobilized onto agarose microbeads exerted some protective effect in xenogeneic islets resulting in prolonged graft survival in diabetic patients using xenotransplantation model (rats to mice).