J
Jong Ik Hwang
Researcher at Korea University
Publications - 82
Citations - 2234
Jong Ik Hwang is an academic researcher from Korea University. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 22, co-authored 76 publications receiving 1851 citations. Previous affiliations of Jong Ik Hwang include Hanwha L&C.
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Journal ArticleDOI
Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates
Yeo Reum Lee,K Tsunekawa,Mi Jin Moon,Haet Nim Um,Jong Ik Hwang,Tomohiro Osugi,Naohito Otaki,Yuya Sunakawa,Kyungjin Kim,Hubert Vaudry,Hyuk Bang Kwon,Jae Young Seong,Kazuyoshi Tsutsui +12 more
TL;DR: This study is the first to identify a mature form of KiSS-2 product in the brain of any vertebrate, and shed new light on the molecular evolution of the kisspeptin-GPR54 system in vertebrates.
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Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation
TL;DR: The data demonstrate that KEAP1 is involved in the negative regulation of NF-kappaB signaling through the inhibition of IKK beta phosphorylation and the mediation of autophagy-dependent IKKbeta degradation.
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Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III
Dong Kyu Kim,Seongsik Yun,Gi Hoon Son,Jong Ik Hwang,Cho Rong Park,Jae Il Kim,Kyungjin Kim,Hubert Vaudry,Jae Young Seong +8 more
TL;DR: The results suggest that the SPX, GAL, and KISS genes arose through local duplications before 2 rounds (2R) of whole-genome duplication, and identify the coevolution of SPX/GAL/KISS ligand genes with their receptor genes.
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Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
Da Young Oh,Jung Min Yoon,Mi Jin Moon,Jong Ik Hwang,Han Choe,Ju Yeon Lee,Jae Il Kim,Sunoh Kim,Hyewhon Rhim,David K. O’Dell,J. Michael Walker,Heung Sik Na,Min Goo Lee,Hyuk Bang Kwon,Kyungjin Kim,Jae Young Seong +15 more
TL;DR: Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr97, Gly98, Phe101, and Arg267 of Gpr92 are responsible for the interaction of G PR92 with FPP and NAG.
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Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: Secrets hidden in genomes
Dong Kyu Kim,Eun Bee Cho,Mi Jin Moon,Sumi Park,Jong Ik Hwang,Olivier Kah,Stacia A. Sower,Hubert Vaudry,Jae Young Seong +8 more
TL;DR: The present review discusses the evolutionary mechanism of vertebrate GnRHs and GnRHRs based on extensive genome comparison, focusing only on vertebrate genomes because of the difficulty in comparing invertebrate and vertebrates genomes due to their marked divergence.