J
Jaeseok Yang
Researcher at Seoul National University Hospital
Publications - 212
Citations - 3173
Jaeseok Yang is an academic researcher from Seoul National University Hospital. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 27, co-authored 180 publications receiving 2740 citations. Previous affiliations of Jaeseok Yang include Seoul National University & Charles R. Drew University of Medicine and Science.
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Journal ArticleDOI
Allograft rejection mediated by memory T cells is resistant to regulation.
Jaeseok Yang,Matthew O. Brook,Manuela Carvalho-Gaspar,Jidong Zhang,Hilda E. Ramon,Mohamed H. Sayegh,Kathryn J. Wood,Laurence A. Turka,Laurence A. Turka,Nick D. Jones,Nick D. Jones +10 more
TL;DR: Data indicate that the relative resistance of both CD4+ and CD8+ alloreactive memory T cells to regulation may mediate resistance to tolerance induction seen in hosts with preexisting alloantigen-specific immunity and further indicate the multiplicity of mechanisms by which Tregs may control alloimmune responses in vivo.
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Chronic asymptomatic pyuria precedes overt urinary tract infection and deterioration of renal function in autosomal dominant polycystic kidney disease
Jin Ho Hwang,Hayne Cho Park,Jong Cheol Jeong,Seon Ha Baek,Mi Yeun Han,Kitae Bang,Jeong Yeon Cho,Suk Hee Yu,Jaeseok Yang,Kook Hwan Oh,Young Hwan Hwang,Curie Ahn +11 more
TL;DR: Chronic asymptomatic pyuria may increase the risk of developing overt UTI and may contribute to declining renal function in ADPKD.
Journal ArticleDOI
Hypoxia inducible factor 1α regulates T cell receptor signal transduction
Aaron K. Neumann,Jaeseok Yang,Mangat P. Biju,Suresh K. Joseph,Randall S. Johnson,Volker H. Haase,Bruce D. Freedman,Laurence A. Turka +7 more
TL;DR: It is found that constitutive activity of Hif-1α resulted in diminished Ca2+ response upon TCR crosslinking despite equivalent activation of phospholipase Cγ1, normal intracellularCa2+ stores, and normal entry of Ca 2+ across the plasma membrane.
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The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model
Takuya Ueno,Antje Habicht,Michael R. Clarkson,Monica J. Albin,Kazuhiro Yamaura,Olaf Boenisch,Joyce Popoola,Ying Wang,Hideo Yagita,Hisaya Akiba,M. Javeed Ansari,Jaeseok Yang,Laurence A. Turka,David M. Rothstein,Robert F. Padera,Nader Najafian,Mohamed H. Sayegh +16 more
TL;DR: Previously unknown functions of TIM-1 in regulating alloimmune responses in vivo are defined and may provide a novel approach to promoting transplantation tolerance.
Journal ArticleDOI
Mechanisms Underlying Blockade of Allograft Acceptance by TLR Ligands
Paige M. Porrett,Xueli Yuan,David F. LaRosa,Patrick T. Walsh,Jaeseok Yang,Jaeseok Yang,Wenda Gao,Peiying Li,Jidong Zhang,Javeed M. Ansari,Wayne W. Hancock,Mohamed H. Sayegh,Maria Koulmanda,Terry B. Strom,Laurence A. Turka +14 more
TL;DR: The data suggest that TLR signals do not prevent prolonged graft acceptance by directing natural Tregs into the Th17 lineage or by using other IL-6-dependent mechanisms, and that graft destruction results from the ability of CpG to drive Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4+Foxp3+ T Regs.