Zinc as an anti-tumor agent in prostate cancer and in other cancers
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TLDR
Zinc accumulation in prostate cells is regarded as a tumor suppressor gene in prostate cancer because of the expression and activity of the zinc uptake transporter, ZIP1, which exhibits anti-proliferative effects via its induction of mitochondrial apoptogenesis.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2007-07-15 and is currently open access. It has received 207 citations till now. The article focuses on the topics: Prostate cancer & Prostate.read more
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Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
TL;DR: A better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
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Novel metals and metal complexes as platforms for cancer therapy.
Michael Frezza,Sarmad Sahiel Hindo,Di Chen,Andrew Davenport,Sara M. Schmitt,Dajena Tomco,Q. Ping Dou +6 more
TL;DR: The use of nonessential metals as probes to target molecular pathways as anticancer agents is also emphasized in this article, where the design of coordination complexes for cancer treatment is reviewed and design strategies and mechanisms of action are discussed.
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Zinc in Specialized Secretory Tissues: Roles in the Pancreas, Prostate, and Mammary Gland
TL;DR: The pancreas, prostate, and mammary gland are secretory tissues that have unusual Zn requirements and thus must tightly regulate Zn metabolism through integrating Zn import, sequestration, and export mechanisms, which is tightly regulated through the integration of Zn transporting mechanisms.
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The important role of the apoptotic effects of zinc in the development of cancers
TL;DR: The effects of zinc in the regulation of apoptosis appear to be cell type specific and one must be mindful of the experimental conditions under which zinc effects are investigated relative to the physiological and pathological conditions of zinc distribution and concentrations that can exist in situ.
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Zinc and liver disease.
TL;DR: Clinical trials in human liver disease are limited in size and quality, but it is clear that zinc supplementation reverses clinical signs of zinc deficiency in patients with liver disease.
References
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The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
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RAS oncogenes: the first 30 years
TL;DR: The knowledge that has accumulated since their discovery 30 years ago has been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.
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Ras proteins: different signals from different locations
TL;DR: Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes, highlighting the complex interplay between Ras location and function.
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Mammalian zinc transporters
Robert J. McMahon,Robert Cousins +1 more
TL;DR: Describing of a family of zinc transporters bridges the integrative and reductionist approach to the study of zinc metabolism and will provide a clearer understanding of the molecular events that regulate zinc absorption and homeostasis.
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Zinc coordination sphere in biochemical zinc sites
TL;DR: The influence of zinc on quaternary protein structure has led to the identification of a fourth type of zinc binding site, protein interface, which is formed from ligands supplied from amino acid residues residing in the binding surface of two proteins.