Journal ArticleDOI
Zinc-releasing calcium phosphate for stimulating bone formation ☆
Atsuo Ito,Haruo Kawamura,Makoto Otsuka,Masako Ikeuchi,Hajime Ohgushi,Kunio Ishikawa,Kazuo Onuma,Noriko Kanzaki,Yu Sogo,Noboru Ichinose +9 more
TLDR
Findings suggest that the zinc-containing tricalcium phosphate is a biomaterial that has a pharmaceutical effect of promoting bone formation.About:
This article is published in Materials Science and Engineering: C.The article was published on 2002-10-01. It has received 258 citations till now. The article focuses on the topics: Zinc.read more
Citations
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Journal ArticleDOI
Calcium phosphate-based osteoinductive materials.
TL;DR: This review focuses on calcium phosphate-based bone substitute materials that are used (or can be used) for teeth or bone replacement, bone repair, augmentation, or regeneration and will also include some properties of bone (e.g., interconnected porosity, biodegradability, bioactivity, osteoconductivity) that are being mimicked in the manufacture of calcium phosphates.
Journal ArticleDOI
Substituted hydroxyapatites for biomedical applications: A review
TL;DR: In this paper, a review summarizes recent and very recent work on preparing substituted hydroxyapatites for a wide range of biomedical applications, including repairing and replacing diseased and damaged parts of musculoskeletal systems and also as a drug or gene delivery agent, as a bioactive coating on metallic osseous implants, biomagnetic particles and fluorescent markers.
Journal ArticleDOI
How smart do biomaterials need to be? A translational science and clinical point of view ☆
Boris Michael Holzapfel,Johannes C. Reichert,Jan-Thorsten Schantz,Uwe Gbureck,Lars Rackwitz,Ulrich Nöth,Franz Jakob,Maximilian Rudert,Jürgen Groll,Dietmar W. Hutmacher +9 more
TL;DR: The purpose of the review is to assess state of the art and future perspectives of the so called "smart biomaterials" from a translational science and specifically clinical point of view and to filter out and discuss which biomedical advances and innovations help to achieve the objective to translate smart biomMaterials from bench to bedside.
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Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TL;DR: This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.
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A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response:
TL;DR: The challenges used to overcome the functional loss of glucose sensors, restenosis after stent implantation, and calcification induced by implantable devices are discussed.
References
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Book
Trace Elements in Human and Animal Nutrition
TL;DR: This book discusses the history of zinc, its application in agriculture, and its applications in the management of soil-Plant-Animal relations.
Journal ArticleDOI
Stimulatory effect of zinc on bone formation in tissue culture.
TL;DR: The findings indicate that the zinc had a direct stimulatory effect on bone mineralization in vitro, and that bone protein synthesis was a necessary component of this response.
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Preparation, solubility, and cytocompatibility of zinc‐releasing calcium phosphate ceramics
TL;DR: Zinc was doped into beta-tricalcium phosphate to develop zinc-releasing biomaterials to promote bone formation and Proliferation of osteoblastic MC3T3-E1 cells was significantly increased on the composite ceramic with a zinc content from 0.6 to 1.20 wt %.
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Zinc is a potent inhibitor of osteoclastic bone resorption in vitro
TL;DR: Zinc is a highly potent and selective inhibitor of osteoclastic bone resorption in vitro and may represent a novel inhibitory mechanism in the osteoclast.
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Action of zinc on bone metabolism in rats. Increases in alkaline phosphatase activity and DNA content.
TL;DR: The present investigation suggests that zinc may induce the increase in alkaline phosphatase related to DNA synthesis and, as a result, stimulate bone growth.