How alteration in acetylation status might affect nuclear deformations and nuclear blebbing?
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Alterations in acetylation status can impact nuclear deformations and blebbing by influencing nuclear architecture and stability. Acetylation, a crucial post-translational modification, regulates histone and non-histone proteins involved in various cellular processes, including nuclear integrity. Studies on cloned embryos show that histone acetylation levels in donor cells correlate with developmental potential, affecting cloning efficiency and nuclear stability. Additionally, induced differentiation in stem cells and cancer cells results in changes in histone acetylation patterns, indicating a role in cellular differentiation and nuclear structure. These findings suggest that acetylation alterations can lead to nuclear abnormalities, chromosomal instability, and impaired nuclear mechanostability, ultimately affecting nuclear deformations and blebbing.
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9 Citations | Changes in histone acetylation status during cell differentiation can influence nuclear deformations and blebbing by modulating chromatin structure and gene expression, impacting nuclear morphology. |
| Not addressed in the paper. | |
55 Citations | Alteration in lamin A/C acetylation affects nuclear deformations by increasing solubility, impairing phosphorylation dynamics, and compromising nuclear mechanostability, leading to nuclear abnormalities and blebbing. |
1 Citations | Alteration in acetylation status, such as treatment with NaBu, can impact histone acetylation levels and improve development of cloned embryos, potentially influencing nuclear deformations and blebbing during nuclear transfer. |
| Altered protein acetylation can impact nuclear deformations and blebbing by influencing the regulation of nuclear proteins involved in RNA metabolism and localization. |
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