How do I apply for mutation of property online in AP?
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75 Citations | The existence of different types of mutation therefore means that diverse ap- proaches to mutation detection are required. |
75 Citations | Mutation detection procedures can thus be tailored to the partic- ular gene of interest if such a predisposition exists or designed to detect virtually all types of mutation for a more universal ap- proach. |
75 Citations | The AP site-induced mutation spectrum supports evidence for the 'A-rule' and is also consistent with the use of the 5' neighbouring base to instruct nucleotide incorporation (5'-rule). |
| Nonetheless, under sufficient selection, AP is often resolvable through regulatory evolution, primarily by trans-acting changes, although in one case we also detected a cis-acting change and localized its causal mutation. | |
33 Citations | Our data point to two independent and additive effects of FLG mutations: i) carrying a mutation and ii) having a mutation carrier mother. |
32 Citations | The search for mutation is also useful for the identification of the family members who do not carry the mutation and can avoid unnecessary biochemical and instrumental evaluations. |
15 Citations | In this method, experimental conditions do not need to be altered depending on mutation sites, and it should be the alternative method for mutation screening. |
30 Citations | In particular, antagonistic pleiotropy (“AP”: when a mutation has opposite fitness effects in different environments) generates tradeoffs, which may constrain adaptation. |
| We conclude this nucleotide site is not a mutation hot spot even after accounting for possible Luria–Delbruck “mutation jackpots.” An alternative explanation for such foci involving positive selection acting on adult self-renewing Ap spermatogonia experiencing the rare mutation could not be rejected. | |
| In vitro assays suggest that this mutation causes a “gain of function” in the transcriptional activation of AP-2α. |
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