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Ingo Marenholz
Researcher at Charité
Publications - 61
Citations - 6041
Ingo Marenholz is an academic researcher from Charité. The author has contributed to research in topics: Genome-wide association study & Atopic dermatitis. The author has an hindex of 30, co-authored 56 publications receiving 5193 citations. Previous affiliations of Ingo Marenholz include Humboldt University of Berlin & Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)
TL;DR: This work analyzed the structural variations, which are the basis of functional diversification, as well as the genomic organization of the S100 family in human and compared it with the S 100 repertoires in mouse and rat, and identified evolutionary related subgroups of S100 proteins within the three species.
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Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex (“Epidermal Differentiation Complex”) on Human Chromosome 1q21
TL;DR: It is concluded that these loci constitute a gene complex, for which the name epidermal differentiation complex is proposed, since calcium levels tightly control the differentiation of epithelial cells and the expression of genes encoding epidersmal structural proteins.
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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Lavinia Paternoster,Marie Standl,Johannes Waage,H. Baurecht,Melanie Hotze,David P. Strachan,John A. Curtin,Klaus Bønnelykke,Chao Tian,Atsushi Takahashi,Jorge Esparza-Gordillo,Alexessander Couto Alves,Jacob P. Thyssen,Herman T. den Dekker,Manuel A. R. Ferreira,Elisabeth Altmaier,Patrick M. A. Sleiman,Patrick M. A. Sleiman,Feng Li Xiao,Juan R. González,Juan R. González,Ingo Marenholz,Birgit Kalb,Maria Pino-Yanes,Maria Pino-Yanes,Cheng-Jian Xu,Lisbeth Carstensen,Maria M. Groen-Blokhuis,Cristina Venturini,Craig E. Pennell,Sheila J. Barton,Albert M. Levin,Ivan Curjuric,Ivan Curjuric,Mariona Bustamante,Eskil Kreiner-Møller,Gabrielle A. Lockett,Jonas Bacelis,Supinda Bunyavanich,Rachel A. Myers,Anja Matanovic,Ashok Kumar,Joyce Y. Tung,Tomomitsu Hirota,Michiaki Kubo,Wendy L. McArdle,A. John Henderson,John P. Kemp,John P. Kemp,Jie Zheng,George Davey Smith,Franz Rueschendorf,Anja Bauerfeind,Min Ae Lee-Kirsch,Andreas Arnold,Georg Homuth,Carsten Oliver Schmidt,Elisabeth Mangold,Sven Cichon,Thomas Keil,Elke Rodriguez,Annette Peters,Andre Franke,Wolfgang Lieb,Natalija Novak,Regina Foelster-Holst,Momoko Horikoshi,Juha Pekkanen,Sylvain Sebert,Lise Lotte N. Husemoen,Niels Grarup,Johan C. de Jongste,Fernando Rivadeneira,Albert Hofman,Vincent W. V. Jaddoe,Suzanne G.M.A. Pasmans,Niels J. Elbert,André G. Uitterlinden,Guy B. Marks,Philip J. Thompson,Melanie C. Matheson,Colin F. Robertson,Janina S. Ried,Jin Li,Xian Bo Zuo,X. Zheng,Xianyong Yin,Liangdan Sun,Maeve A. McAleer,Grainne M. O'Regan,Caoimhe M. R. Fahy,Linda E. Campbell,Milan Macek,Michael Kurek,Donglei Hu,Celeste Eng,Dirkje S. Postma,Bjarke Feenstra,Frank Geller,Jouke-Jan Hottenga,Christel M. Middeldorp,Pirro G. Hysi,Veronique Bataille,Tim D. Spector,Carla M. T. Tiesler,Elisabeth Thiering,Badri Pahukasahasram,James J. Yang,Medea Imboden,Scott Huntsman,Natalia Vilor-Tejedor,Caroline L Relton,Ronny Myhre,Wenche Nystad,Adnan Custovic,Scott T. Weiss,Deborah A. Meyers,Cilla Soederhaell,Erik Melén,Carole Ober,Benjamin A. Raby,Angela Simpson,Bo Jacobsson,John W. Holloway,Hans Bisgaard,Jordi Sunyer,Nicole Probst-Hensch,L. Keoki Williams,Keith M. Godfrey,Carol A. Wang,Dorret I. Boomsma,Mads Melbye,Gerard H. Koppelman,Deborah Jarvis,W.H. Irwin McLean,Alan D. Irvine,Xuejun Zhang,Hakon Hakonarson,Christian Gieger,Esteban G. Burchard,Nicholas G. Martin,Liesbeth Duijts,Allan Linneberg,Marjo-Riitta Järvelin,Markus M. Noethen,Susanne Lau,Norbert Huebner,Young-Ae Lee,Mayumi Tamari,David A. Hinds,Daniel Glass,Sara J. Brown,Joachim Heinrich,David M. Evans,Stephan Weidinger +154 more
TL;DR: This paper performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies.
Journal ArticleDOI
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Manuel A. R. Ferreira,Judith M. Vonk,Hansjörg Baurecht,Ingo Marenholz,Ingo Marenholz,Chao Tian,Joshua D. Hoffman,Quinta Helmer,Annika Tillander,Vilhelmina Ullemar,Jenny van Dongen,Yi Lu,Franz Rüschendorf,Jorge Esparza-Gordillo,Jorge Esparza-Gordillo,Jorge Esparza-Gordillo,Chris W. Medway,Edward Mountjoy,Kimberley Burrows,Oliver Hummel,Sarah Grosche,Sarah Grosche,Ben Michael Brumpton,Ben Michael Brumpton,John S. Witte,Jouke-Jan Hottenga,Gonneke Willemsen,Jie Zheng,Elke Rodriguez,Melanie Hotze,Andre Franke,Joana A. Revez,Jonathan Beesley,Melanie C. Matheson,Shyamali C. Dharmage,L. Bain,Lars G. Fritsche,Maiken Elvestad Gabrielsen,Brunilda Balliu,Jonas B. Nielsen,Wei Zhou,Kristian Hveem,Arnulf Langhammer,Oddgeir L. Holmen,Mari Løset,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Cristen J. Willer,Andreas Arnold,Georg Homuth,Carsten Oliver Schmidt,Philip J. Thompson,Nicholas G. Martin,David L. Duffy,Natalija Novak,Holger Schulz,Stefan Karrasch,Christian Gieger,Konstantin Strauch,Ronald B. Melles,David A. Hinds,Norbert Hubner,Stephan Weidinger,Patrik K. E. Magnusson,Rick Jansen,Eric Jorgenson,Young-Ae Lee,Young-Ae Lee,Dorret I. Boomsma,Catarina Almqvist,Catarina Almqvist,Robert Karlsson,Gerard H. Koppelman,Lavinia Paternoster +73 more
TL;DR: A genome-wide association study of a broad allergic disease phenotype that considers the presence of any one of these three diseases identified 136 independent risk variants, including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology.
Journal ArticleDOI
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.
Ingo Marenholz,Renate Nickel,Franz Rüschendorf,Florian Schulz,Jorge Esparza-Gordillo,Tamara Kerscher,Christoph Grüber,Susanne Lau,Margitta Worm,Thomas Keil,Michael Kurek,Elisabetha Zaluga,Ulrich Wahn,Young-Ae Lee +13 more
TL;DR: The results suggest that the maintenance and repair of the epidermal barrier in infants with eczema may prevent the subsequent development of allergic airways disease.