How does a high fat diet affect the glymphatyc system?
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A high-fat diet impacts the glymphatic system differently based on the study. Research by Delle et al. found that long-term high-fat diet consumption did not significantly affect glymphatic transport globally, except for an increase in influx in the hypothalamus. In contrast, a study by Lima et al. demonstrated that a high-fat diet led to elevated O-GlcNAc modification in arteries, contributing to increased contractile responses and activation of the MAPK pathway in the rat basilar artery. These findings suggest that while the glymphatic system in the brain may not be globally affected by a high-fat diet, vascular function and structure in arteries can be influenced, potentially impacting overall brain health and function.
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| A long-term high-fat diet increases glymphatic activity in the hypothalamus, potentially enhancing metabolic waste clearance in this brain region without major effects elsewhere. |
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