How does platelets increase in dengue?
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125 Citations | We present here the first evidence that dengue type 2 virus binds to human platelets only in the presence of virus-specific antibody, supporting a role for immune-mediated clearance of platelets in the pathogenesis of thrombocytopenia in DHF/DSS. |
| These findings identify inhibition of platelet production in the bone marrow as a key mechanism underlying dengue-induced thrombocytopenia and suggest the utility of the improved humanized mouse model in studying dengue virus infection and pathogenesis in a human cell context. | |
140 Citations | Nevertheless, hemorrhage in dengue without circulatory collapse is most likely due to activation of platelets rather than coagulopathy, which is well compensated. |
| Thus, platelets are frequently affected in dengue, either for alteration of their own functionality, for “silent transport” of virus, or as an anti-viral immune cell. | |
19 Citations | Mean platelet volume is not important as prognostic parameter in dengue fever. |
84 Citations | These data demonstrate that human platelets adhere to dengue-2 virus-stimulated HUVEC and this interaction could contribute to the thrombocytopenia observed during infection. |
Related Questions
How dengue affect platelet count?5 answersDengue virus infection affects platelet count by causing thrombocytopenia, which is a decrease in platelet levels. Thrombocytopenia is observed in both mild and severe cases of dengue, with the lowest platelet counts seen in severe cases. The decrease in platelet counts can be attributed to various mechanisms, including bone marrow suppression, consumption of platelets at the periphery, and platelet clearance mediated by anti-platelet antibodies. Additionally, the formation of viral antibody complexes stimulates platelet aggregation, leading to a decrease in platelet count. Dengue infection also affects platelet function, with alterations in platelet number and function contributing to thrombocytopenia. Platelets play a role in the immune and inflammatory response during dengue infection, and their activation and secretion of viral and host factors contribute to the pathogenesis of the disease. Overall, dengue infection has a significant impact on platelet count and function, highlighting the importance of monitoring platelet levels in dengue patients.
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