How has the classification system for cancer evolved over time and what factors have influenced these changes?
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The classification system for cancer has evolved over time due to several factors. Traditionally, cancers were classified based on anatomical location, but advancements in cancer genomics have led to a paradigm shift in classification . The World Health Organization (WHO) and the Union for International Cancer Control (UICC) have incorporated biologic and molecular-genetic features into their classifications, which has had a significant impact on cancer diagnosis and treatment . The development of molecular profiling technologies, such as multi-regional sequencing and single cell analysis, has provided a better understanding of the genomic, transcriptomic, and epigenetic mechanisms of cancer, leading to a renewed interest in the analysis of these factors . Additionally, the recognition of the importance of evolutionary and ecological processes in cancer has led to the proposal of a framework for classifying tumors based on intratumoral heterogeneity, changes over time, hazards to neoplastic cell survival, and available resources . These changes in the classification system have the potential to personalize interventions based on the evolvability of the patient's tumor .
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| Papers (5) | Insight |
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| The classification system for cancer has evolved from anatomical location-based to molecular targeted therapies based on specific genetic mutations in tumors. This shift is influenced by the development of molecular targeted therapies and the identification of class-specific and drug-specific toxicities. | |
| The paper discusses the evolution of cancer classification from organ-based naming to finer subtypes based on clinical and biological features. Factors influencing changes include genomic data, larger sample cohorts, diverse -omics data types, and gene-gene correlations. | |
| The paper proposes a framework for classifying tumors based on evolutionary and ecological factors, but does not discuss the evolution of the classification system over time or the factors that have influenced these changes. | |
| The classification system for cancer has evolved to include biologic and molecular-genetic features, which have been influenced by advances in cancer genomics. | |
| The provided paper does not discuss the evolution of the classification system for cancer or the factors that have influenced these changes. |
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