What is known about beta cell gene expression and maturation postnatally. until what age are beta cells considered mature?
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Postnatally, beta cell maturation is a crucial process for establishing functional maturity. Key genes associated with human pancreatic beta cell maturation include Urocortin-3 (UCN3), CHGB, G6PC2, FAM159B, GLUT1, IAPP, and ENTPD3, which show developmental correlation with functional maturation. The transition from immature to mature beta cells involves the initiation of functional maturation before birth, with completion in early postnatal life. Glucose-induced insulin secretion, a hallmark of mature beta cells, is achieved postnatally after a phase of intense proliferation, crucial for establishing an appropriate functional beta cell mass. The neonatal period is decisive for acquiring an adequate functional beta cell mass, with glucose-responsive insulin secretion being a key indicator of maturity. The exact age at which beta cells are considered fully mature is not explicitly mentioned in the provided contexts.
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3 Citations | Postnatally, beta cell gene expression undergoes maturation, with intense proliferation before glucose-induced insulin secretion. Key regulator Scrt1 controls beta cell proliferation, and maturity extends beyond the neonatal period. |
| Postnatally, beta cell maturation involves shifts in energy-sensing pathways and nutrient exposure, leading to functional maturity. Beta cells are considered mature post-weaning and continue to develop thereafter. | |
| Postnatal beta-cell gene expression transitions from cell development pathways to metabolic processes. Beta cells are considered mature around 60 days postnatal age. | |
| Beta cell maturation markers like CHGB, FAM159B, G6PC2, GLUT1, IAPP, and ENTPD3 show increased expression postnatally, indicating maturity onset after birth. Age of beta cell maturity not specified. | |
| Postnatal beta cells undergo maturation marked by upregulation of NEUROD1, UCN3, ABCC8, and CASR genes. Beta cells are considered mature after achieving full glucose responsiveness postnatally. |
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