What is known of the effect of cannabinoids on attention?
Best insight from top research papers
Cannabinoids have been studied for their effects on attention. Research indicates that cannabinoids, including cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), can influence attention and cognitive processes. While CBD alone did not affect attention in healthy volunteers, THC was found to impair cognitive processing speed and attention. Additionally, the endocannabinoid system, which is influenced by exogenous cannabinoids like THC, plays a role in modulating motivation and attention through interactions with the mesocorticolimbic dopamine pathway. Studies have shown that acute administration of cannabinoids can impact attentional capacity and impulsivity in rodent models. Further research is needed to fully understand the complex interactions between cannabinoids and attention processes.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| Consumption of synthetic cannabinoids in adults with ADHD is associated with stronger ADHD symptom severity, indicating a potential negative impact on attention. | |
| Cannabinoid receptor 1 positive allosteric modulator GAT211 did not significantly affect attention in rats, while acute MK-801 impaired visual attention and increased impulsivity in the study. | |
5 Citations | The paper discusses the intertwined relationship between cannabinoids and attentional processes, specifically in the context of the 5-choice serial reaction time task and the attentional set-shifting task. However, the specific effects of cannabinoids on attention are not clearly stated in the paper. |
16 Citations | The paper states that THC impaired attention in healthy volunteers, but CBD alone did not have any effect on attention. However, the study did not find any evidence that CBD pre-treatment mitigated the detrimental effects of THC on attention. |
| The paper states that cannabinoids have been reported to have pharmacological effects on ADHD symptoms, including reducing hyperactivity and improving focus and control of impulsive behavior. |
Related Questions
What is the effect of cannabis in the brain?3 answersCannabis has been found to have various effects on the brain. Animal and in vitro studies have shown that cannabis can have a detrimental effect on neuronal integrity, causing DNA damage, cell shrinkage, atrophy, and apoptosis. Clinical studies have also indicated negative impacts, such as raised serum levels of proinflammatory cytokines, increased oxidative stress biomarkers, and reduced antioxidants in chronic cannabis users. Additionally, cannabis use during adolescence has been associated with structural and functional alterations in frontal and limbic regions of the brain, potentially affecting cognitive functions like working memory, attention, inhibitory control, and decision-making. Preclinical models suggest that factors such as amount and frequency of cannabis use, potency, psychiatric comorbidity, and polysubstance use contribute to the behavioral vulnerability associated with adolescent cannabis exposure. Overall, the evidence suggests that cannabis can have negative effects on brain structure and function, particularly when used chronically or during adolescence.
How does cannabis effect the brain?5 answersCannabis affects the brain through its interactions with specific receptors in the brain, particularly the endocannabinoid system. The primary psychoactive component of cannabis, tetrahydrocannabinol (THC), interacts with CB1 cannabinoid receptors in the brain, leading to changes in neuronal functioning and synaptic plasticity. Long-term exposure to THC, especially during adolescence, can disrupt neurotransmitter signaling systems and result in cognitive deficits and altered behavior. Animal and clinical studies have shown that cannabis and THC can have detrimental effects on brain structure and function, including DNA damage, cell shrinkage, atrophy, and apoptosis. Adolescent cannabis use has been associated with structural and functional alterations in brain regions involved in cognition and behavior, potentially leading to behavioral vulnerability. Additionally, cannabis use has been linked to increased oxidative stress and proinflammatory cytokine levels in chronic users. Overall, the evidence suggests that cannabis can have negative effects on brain health and cognitive function.
Do cannabinoids have any effect on the fertility of humans or animals?3 answersCannabinoids, including both exogenous and endogenous cannabinoids, have been shown to have effects on fertility in both humans and animals. In females, cannabinoids can affect various aspects of reproductive function, including sexual desire and receptivity, folliculogenesis, ovulation, and oviductal transport. In males, cannabinoids can impact testicular morphology, sperm parameters, and male reproductive hormones, leading to reduced fertility. However, the exact effects of cannabinoids on fertility are still not fully understood, and more research is needed to determine the mechanisms and reversibility of these effects. It is important to note that most of the evidence available is from pre-clinical studies, and further well-controlled studies are required to evaluate the effects of cannabinoids on fertility in both humans and animals.
How does cannabis affect the mind?5 answersCannabis affects the mind by interacting with the endocannabinoid (eCB) system, which plays a crucial role in the changes that occur in the adolescent brain. The use of cannabis can lead to adverse psychiatric effects such as anxiety and acute psychosis. Research has shown that recreational cannabis use, especially at a young age, can undermine cognition and alter brain structure and function. Chronic cannabis use has been associated with cognitive impairment and has been identified as a risk factor for schizophrenia. Cannabis use can affect the processing of social information, similar to other risk factors for psychosis. The effects of cannabis on mental functions, such as sense of self and transcendence, are complex and not fully understood.
How do cannabinoids affect attention?5 answersCannabinoids have been found to affect attention by producing impairments in cognitive abilities such as working memory, attentional function, and reversal learning. The effects of cannabinoids on attention are mediated through the activation of the CB1 cannabinoid receptor. Synthetic cannabinoids (SC) consumption in adults with attention-deficit/hyperactivity disorder (ADHD) is associated with stronger ADHD symptom severity. The novel CB1 agonist AM 4054 has been shown to decrease accuracy in an operant reaction time task, impairing performance on one lever while sparing the other. Additionally, AM 4054 enhances expectancy and diminishes stimulus control, leading to decreased accuracy in reporting less frequent cues. These findings suggest that cannabinoids can have both impairing and enhancing effects on attention, depending on the specific cannabinoid and the task being performed.
How cannabinoid effect to neurotransmitter?5 answersCannabinoids รวมทั้งΔ1-THC และ CBD ได้รับการแสดงเพื่อยับยั้งการดูดซึมของสารสื่อประสาทเช่น norepinephrine, dopamine, γ-aminobutyric acid (GABA) และเซโรโทนินโดยไซแนปโตโซมสมองของเมาส์Endocannabinoids ซึ่งถูกปล่อยออกมาจากเซลล์ประสาท postsynaptic ทำหน้าที่เป็นผู้ส่งสารถอยหลังเข้าคลองเพื่อปรับการส่งผ่านแบบซินแนปติกและระงับการปล่อยสารสื่อประสาทที่ตามมาการเปิดใช้งาน GPR55 ซึ่งเป็นตัวรับโปรตีน G ที่ไวต่อแคนนาบินอยด์บางชนิด เพิ่มความน่าจะเป็นในการปลดปล่อยที่ไซแนปส์แต่ละตัวในฮิปโปแคมปัสตัวรับ cannabinoid CB1 เมื่อเปิดใช้งานโดย agonists ภายนอกหรือ endocannabinoids ทำให้เกิดการยับยั้ง pressynaptic ของการปล่อยสารสื่อประสาทในระบบประสาทส่วนกลางEndocannabinoids ทำหน้าที่เป็นผู้ส่งสารถอยหลังเข้าคลอง มีบทบาทในเส้นทางสื่อสารระหว่างเซลล์ในวงจรประสาท.