Erik B. Oleson

TL;DR: These studies suggest that hypocretin neurotransmission participates in reinforcement processes, likely through modulation of the mesolimbic dopamine system, and suggest that the hypoc retin system may provide a target for pharmacotherapies to treat cocaine addiction.

TL;DR: Data show that subsecond fluctuations in mesolimbic dopamine release predict when rats will successfully avoid punishment and differentially encode cues related to aversive outcomes.

TL;DR: Behavioral and neurochemical data derived from Homer1 mutant mice are consistent with the recent association of schizophrenia with a single‐nucleotide polymorphism in the Homer1 gene and suggest that the regulation of extracellular levels of glutamate within limbo‐corticostriatal structures by Homer 1 gene products may be involved in the pathogenesis of this neuropsychiatric disorder.

TL;DR: Constitutive Homer2 gene deletion and rescue with adeno-associated viral transfection of Homer2b was used to demonstrate the importance of Homer proteins in neuroplasticity produced by repeated ethanol (EtOH) administration and a necessary and active role for accumbens Homer2 expression in regulating EtOH-induced behavioral and cellular neuroplasticsity.

TL;DR: It is suggested that 2AG in the VTA regulates reward seeking by sculpting ethologically relevant patterns of dopamine release during reward-directed behavior by augmenting levels of the endocannabinoid 2-arachidonoylglycerol (2AG).