F
F. Markus Leweke
Researcher at University of Sydney
Publications - 114
Citations - 6651
F. Markus Leweke is an academic researcher from University of Sydney. The author has contributed to research in topics: Schizophrenia & Psychosis. The author has an hindex of 39, co-authored 106 publications receiving 5701 citations. Previous affiliations of F. Markus Leweke include Ministry of Health (New South Wales) & University of Cologne.
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Journal ArticleDOI
Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology.
Oliver D. Howes,Robert A. McCutcheon,Ofer Agid,Andrea de Bartolomeis,Nico J.M. van Beveren,Michael L. Birnbaum,Michael A P Bloomfield,Rodrigo A. Bressan,Robert W. Buchanan,William T. Carpenter,David J. Castle,Leslie Citrome,Zafiris J. Daskalakis,Michael Davidson,Richard J. Drake,Serdar M. Dursun,Bjørn H Ebdrup,Helio Elkis,Peter Falkai,W. Wolfgang Fleischacker,Ary Gadelha,Fiona Gaughran,B. Glenthøj,Ariel Graff-Guerrero,Jaime Eduardo Cecílio Hallak,William G. Honer,James L. Kennedy,Bruce J. Kinon,Stephen M. Lawrie,Jimmy Lee,F. Markus Leweke,James H. MacCabe,Carolyn B. McNabb,Herbert Y. Meltzer,Hans-Jürgen Möller,Shinchiro Nakajima,Christos Pantelis,Tiago Reis Marques,Gary Remington,Susan L. Rossell,Bruce R. Russell,Cynthia Siu,Takefumi Suzuki,Iris E. C. Sommer,David Taylor,Neil Thomas,Alp Üçok,Daniel Umbricht,James T.R. Walters,John M. Kane,Christoph U. Correll +50 more
TL;DR: The authors present consensus guidelines that operationalize criteria for determining and reporting treatment resistance, adequate treatment, and treatment response, providing a benchmark for research and clinical translation in schizophrenia.
Journal ArticleDOI
Cerebrospinal Anandamide Levels are Elevated in Acute Schizophrenia and are Inversely Correlated with Psychotic Symptoms
Andrea Giuffrida,F. Markus Leweke,C.W. Gerth,D. Schreiber,D. Schreiber,Dagmar Koethe,Johannes Faulhaber,Joachim Klosterkötter,Daniele Piomelli +8 more
TL;DR: The results suggest that anandamide elevation in acute paranoid schizophrenia may reflect a compensatory adaptation to the disease state, and the endocannabinoids are a family of bioactive lipids that activate CB1 cannabinoid receptors in the brain and exert intense emotional and cognitive effects.
Journal ArticleDOI
Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia.
Elaine Holmes,Tsz M. Tsang,Jeffrey T.-J. Huang,F. Markus Leweke,Dagmar Koethe,C.W. Gerth,Brit M. Nolden,S. Gross,D. Schreiber,Jeremy K. Nicholson,Sabine Bahn +10 more
TL;DR: Findings suggest brain-specific alterations in glucoregulatory processes in the CSF of drug-naïve patients with first-onset schizophrenia, implying that these abnormalities are intrinsic to the disease, rather than a side effect of antipsychotic medication.
Journal ArticleDOI
Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations
Jim van Os,Jim van Os,Bart P. F. Rutten,Inez Myin-Germeys,Philippe Delespaul,Wolfgang Viechtbauer,Catherine van Zelst,Richard Bruggeman,Ulrich Reininghaus,Ulrich Reininghaus,Craig Morgan,Robin M. Murray,Marta Di Forti,Philip McGuire,Lucia Valmaggia,Matthew J. Kempton,Charlotte Gayer-Anderson,Kathryn Hubbard,Stephanie Beards,Simona A. Stilo,Adanna Onyejiaka,François Bourque,Gemma Modinos,Stefania Tognin,Maria Calem,Michael Conlon O'Donovan,Michael John Owen,Peter Holmans,Nigel Williams,Nicholas John Craddock,Alexander Richards,Isla Humphreys,Andreas Meyer-Lindenberg,F. Markus Leweke,Heike Tost,Ceren Akdeniz,Cathrin Rohleder,J. Malte Bumb,Emanuel Schwarz,Köksal Alptekin,Alp Üçok,Meram Can Saka,E. Cem Atbasoglu,Sinan Guloksuz,Sinan Guloksuz,Güvem Gümüş-Akay,Burçin Cihan,Hasan Karadağ,Haldan Soygür,Eylem Sahin Cankurtaran,Semra Ulusoy,Berna Binnur Akdede,Tolga Binbay,Ahmet Ayer,Handan Noyan,Gülşah Karadayı,Elçin Akturan,Halis Ulaş,Celso Arango,Mara Parellada,Miguel Bernardo,Julio Sanjuán,Julio Bobes,Manuel Arrojo,Jose Luis Santos,Pedro Cuadrado,José Juan Rodríguez Solano,Angel Carracedo,Enrique García Bernardo,Laura Roldan,Gonzalo López,Bibiana Cabrera,Sabrina Cruz,Eva Mª Díaz Mesa,María Pouso,Estela Jiménez,Teresa Sánchez,Marta Rapado,Emiliano González,Covadonga Martínez,Emilio Sánchez,Ma Soledad Olmeda,Lieuwe de Haan,Eva Velthorst,Mark van der Gaag,Jean-Paul Selten,Daniella van Dam,Elsje van der Ven,Floor J. van der Meer,Elles Messchaert,Tamar Kraan,Nadine Burger,Marion Leboyer,Andrei Szöke,Franck Schürhoff,Pierre-Michel Llorca,Pierre-Michel Llorca,Stéphane Jamain,Stéphane Jamain,Andrea Tortelli,Flora Frijda,Jeanne Vilain,Anne-Marie Galliot,Grégoire Baudin,Aziz Ferchiou,Jean-Romain Richard,Jean-Romain Richard,E. Bulzacka,Thomas Charpeaud,Thomas Charpeaud,Anne-Marie Tronche,Anne-Marie Tronche,Marc De Hert,Ruud van Winkel,Jeroen Decoster,Catherine Derom,Evert Thiery,Nikos C. Stefanis,Gabriele Sachs,Harald N. Aschauer,Iris Lasser,Bernadette Winklbaur,Monika Schlögelhofer,Anita Riecher-Rössler,Stefan Borgwardt,Anna Walter,Fabienne Harrisberger,Renata Smieskova,Charlotte Rapp,Sarah Ittig,Fabienne Soguel-Dit-Piquard,Erich Studerus,Joachim Klosterkötter,Stephan Ruhrmann,Julia Paruch,Dominika Julkowski,Desiree Hilboll,Pak C. Sham,Stacey S. Cherny,Eric Y.H. Chen,Desmond Campbell,Miaoxin Li,Carlos M. Romeo-Casabona,Aitziber Emaldi Cirión,Asier Urruela Mora,Peter G. Jones,James B. Kirkbride,James B. Kirkbride,Mary Cannon,Dan Rujescu,Ilaria Tarricone,Domenico Berardi,Elena Bonora,Marco Seri,Thomas Marcacci,Luigi Rocco Chiri,Federico Chierzi,Viviana Storbini,Mauro Braca,Maria Gabriella Minenna,Ivonne Donegani,Angelo Fioritti,Daniele La Barbera,Caterina La Cascia,Alice Mulè,Lucia Sideli,Rachele Sartorio,Laura Ferraro,G Tripoli,F. Seminerio,A.M. Marinaro,Patrick D. McGorry,Barnaby Nelson,G. Paul Amminger,Christos Pantelis,Paulo Rossi Menezes,Cristina Marta Del-Ben,Silvia Tenan,Rosana Shuhama,Mirella Ruggeri,Sarah Tosato,Antonio Lasalvia,Chiara Bonetto,Elisa Ira,Merete Nordentoft,Marie-Odile Krebs,Neus Barrantes-Vidal,Paula Cristobal,Thomas R. Kwapil,Elisa Brietzke,Rodrigo A. Bressan,Ary Gadelha,Nadja P. Maric,Sanja Andric,Marina Mihaljevic,Tijana Mirjanic +195 more
TL;DR: A review of the recent developments and how integrated, large-scale investigations may overcome contemporary challenges in G × E research can be found in this paper, drawing on the example of a large, international, multi-center study into the identification and translational application of gene-environment interactions in schizophrenia.
Journal ArticleDOI
Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: Impact of cannabis use
F. Markus Leweke,Andrea Giuffrida,Dagmar Koethe,D. Schreiber,D. Schreiber,Brit M. Nolden,Laura Kranaster,Miriam A. Neatby,Miriam Schneider,C.W. Gerth,Martin Hellmich,Joachim Klosterkötter,Daniele Piomelli +12 more
TL;DR: It is indicated that frequent cannabis exposure may down-regulate anandamide signaling in the CNS of schizophrenic patients, but not of healthy individuals.