What is mechanical drawback of PCL?
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The mechanical drawback of Polycaprolactone (PCL) lies in its inherent stiffness and hydrophobicity, which can hinder cell attachment and proliferation in tissue engineering applications. Studies have shown that while PCL can be reinforced by incorporating other materials like poly(lactic acid) (PLA) fibers to enhance its mechanical properties, such modifications can lead to decreased elongation and strength at break, although the tensile yield strength and modulus are significantly increased . Additionally, the thermal stability of clay organo-modifiers used in PCL nanocomposites can impact the final mechanical performance, especially when subjected to shear forces during processing, affecting the dispersion degree of the clay and overall mechanical properties . Furthermore, the alignment and geometric configurations of 3D printed PCL scaffolds can influence their mechanical behavior, with different pore geometries affecting deformability under compression .
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19 Citations | The mechanical drawback of PCL is localized ductile failure, which tends to be suppressed with increasing PLLA content in the polymer blend, affecting the deformation behavior and properties. |
| The mechanical drawback of PCL is influenced by the thermal stability of clay organo-modifiers, affecting final clay content and dispersion in PCL/clay nanocomposites during processing. | |
| The mechanical drawback of PCL is its deformability, which is significantly affected by the pore geometric configurations of the 3D printed scaffolds under compression. | |
| PCL's mechanical drawback is low stiffness due to its flexible nature, limiting its applications; however, reinforcing with PLA fibers significantly enhances tensile strength and modulus. | |
31 Citations | The mechanical drawback of PCL is its high stiffness, which hinders significant cell attachment and proliferation in cardiac tissue engineering applications. |
Related Questions
What is pcl polymer?5 answersPoly(ϵ-caprolactone) (PCL) is a biodegradable and biocompatible synthetic polymer with attractive physical, chemical, thermal, and mechanical properties. It is widely used in various biomedical and nonmedical applications, including drug delivery, tissue engineering, and controlled release systems. PCL can be modified to alter its chemical structure and degree of crystallinity, which affects its properties. However, PCL has some limitations, such as low mechanical strength, poor bioactivity, and hydrophobicity. To overcome these limitations, researchers have investigated blending PCL with nature-derived polymers and incorporating nanofillers, such as cellulose nanocrystals, to enhance its properties. The formation of novel PCL copolymers, blends, and composites has also been explored to broaden its versatility and applicability. Overall, PCL is a promising polymer with potential for further research and development in the field of biomedicine.
What are the limitations of thermomechanical analysis for polymers?5 answersThermomechanical analysis (TMA) has limitations when applied to polymers. One limitation is the lack of information on the molecular mass distribution of linear polymers and tie chains of cross-linked polymers in the bulk. Another limitation is the sensitivity of TMA to temperature and moisture, which can affect the thermo-mechanical performance of polymeric materials. Additionally, TMA may not be able to detect weaker thermal transitions in polymers, such as β-transitions, that can be observed with other techniques like differential scanning calorimetry (DSC). Furthermore, TMA does not establish a unique relationship between cohesion energy density (CED) and internal pressure (IP) for polymers, as the IP/CED ratio depends on thermodynamic variables and the system of interest. These limitations highlight the need for complementary techniques and considerations when analyzing polymers using TMA.
How does the solvent casting method affect the properties of the PCL films?5 answersSolvent casting method affects the properties of PCL films by influencing the pore size distribution and morphology. Films prepared using chloroform or methylene chloride as solvents are non-porous, while films made with a combination of methylene chloride and dimethylformamide exhibit both uni-modal and bi-modal pore size distributions. The use of porogenic solvents can lead to the formation of microcrystalline structures in the films, which can improve their mechanical properties. Additionally, solvent casting can result in the formation of brittle and inflexible films, but the use of the electrospinning method can enhance the plasticity and mechanical properties of the films. The choice of solvent and casting method can also affect the surface hydrophobicity and contact angle of the films.
Why mechanical skin factor is negative?3 answersThe mechanical skin factor is negative because it results in a flow enhancement. This means that it improves the production rate of the well. Negative skin effects can be caused by factors such as well completion practices, well deviation, and formation damage. These factors can stimulate the reservoir and lead to an increase in oil flow from the reservoir to the surface facilities. The negative skin factor is a dimensionless parameter used to measure the effect of skin on oil production. It indicates that there are no flow restrictions around the wellbore, allowing for a more efficient flow of oil. In contrast, a positive skin factor indicates flow restrictions and a decrease in oil production. Therefore, a negative mechanical skin factor is desirable for optimal gas well performance.
What are the limitation in mechanical properties for PHBV?4 answersThe limitations in the mechanical properties of PHBV include low tensile strength, low flexibility, and insufficient compatibility with other materials. Incorporating natural rubber (NR) into PHBV improves flexibility and toughness but sacrifices tensile strength due to the low modulus of NR and poor compatibility with PHBV. However, the addition of a coagent and peroxide can optimize the mechanical properties of PHBV/NR blends, increasing notched impact strength and tensile strength. Another limitation is the low elongation at break of PHBV, which can be improved by blending it with poly(lactic acid) (PLA) and using a peroxide initiator. Additionally, the mechanical properties of PHBV can be enhanced by incorporating fillers such as hemp fiber or miscanthus biocarbon, which improve modulus but may decrease strength and impact strength. Blending PHBV with other aliphatic polyesters like PCL and PLLA can also improve mechanical properties, such as modulus, strength, and elongation at break.
What difference between PLGA and PCL?2 answersPLGA (poly(lactic-co-glycolic acid)) and PCL (polycaprolactone) are both biodegradable polymers used in drug delivery systems and tissue engineering. PLGA is a copolymer of lactic acid and glycolic acid, while PCL is a polyester derived from caprolactone. PLGA has a faster degradation rate compared to PCL, which is a slow-degrading polymer. Blending PLGA with PCL can improve the mechanical properties, degradation rate, and drug release profiles of the resulting materials. The addition of PLGA to PCL increases the viscosity, facilitating foaming and improving the compression properties of the blend. Blending PCL with PLGA also enhances the roughness, hydrophilicity, tensile strength, and Young's modulus of the material. Furthermore, the blending of PCL with PLGA can provide a suitable physical environment for cell attachment and proliferation in tissue engineering applications. Overall, PLGA and PCL have distinct properties that can be combined through blending to achieve desired characteristics in drug delivery systems and tissue-engineered scaffolds.