What is the origin of GABAAR in human evolution?
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GABAAR subunits in the human brain are organized according to their neurodevelopmental origin, with the majority of cortical GABAergic neurons originating from the ganglionic eminences . The γ2 subunit plays a critical role in maintaining synaptic receptor localization and function, and mutations in this subunit are associated with epilepsy . GABARAPL1, a member of the GABARAP family, is highly expressed in the central nervous system and is involved in various mechanisms such as autophagy, cell death, and tumor progression . The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can be used to evaluate GABAAR-mediated inhibition in the human brain, with TMS-evoked brain potentials (TEPs) serving as biomarkers of local cortical excitability .
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75 Citations | The provided paper does not mention the origin of GABAAR in human evolution. The paper primarily focuses on the functions and regulation of GABARAPL1, a gene that is part of the GABARAP family and is involved in various biological processes such as autophagy, cell death, cell proliferation, and tumor progression. |
| The provided paper does not mention the origin of GABAAR in human evolution. | |
254 Citations | The provided paper does not mention the origin of GABAAR in human evolution. The paper focuses on the developmental origin of neocortical interneurons in primates. |
01 May 2019 32 Citations | The provided paper does not mention the origin of GABAAR in human evolution. |
21 Citations | The provided paper does not mention the origin of GABAAR in human evolution. The paper primarily focuses on the role of the γ2 subunit in GABAAR trafficking and the consequences of human genetic variation. |
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