What is the specific role of Protein Tyrosine Kinase Inhibitor Activity being upregulated in spinal cord injury progression?
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Protein Tyrosine Kinase (PTK) inhibitors play a crucial role in spinal cord injury progression by modulating various pathways. In the context of spinal cord injury, PTK inhibition has been shown to reduce NMDA receptor NR1 subunit expression and translocation, leading to decreased pain-related behaviors . Additionally, the inhibition of Leucine-rich-repeat kinase 2 (LRRK2), a gene associated with neurodegenerative disorders, has been found to counteract pathological consequences of spinal cord trauma, reducing tissue injury and cytokine expression levels . Furthermore, targeting the JAK/STAT3 signaling pathway, downstream of PTK activity, has shown promise in reducing neurogenic heterotopic ossifications following spinal cord injury, highlighting the potential therapeutic impact of PTK inhibitors in mitigating secondary complications .
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19 Citations | The JAK1/2 tyrosine kinase inhibitor reduces neurogenic heterotopic ossification after spinal cord injury by blocking OSM-driven STAT3 phosphorylation, suggesting a potential therapeutic target for NHO. |
| The specific role of LRRK2 inhibition by PF06447475 antagonist in spinal cord injury includes reducing tissue damage, glycogen accumulation, demyelination, oxidative stress, and cytokine expression levels post-trauma. | |
2 Citations | Protein Tyrosine Kinase Inhibitors reduce NMDA NR1 subunit expression, nuclear translocation, and pain behaviors in experimental arthritis, suggesting a pivotal role in pain modulation and neuronal sensitization. |
| The LRRK2 inhibitor PF06447475 reduces neuronal damage and immune response after spinal cord trauma, suggesting a potential role in mitigating neuroinflammatory disorders. |
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