What's the mechanism that noise damage cochlea?
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Excessive sound exposure causes proteotoxicity in the cochlea, leading to noise-induced hearing loss. This is characterized by the accumulation of proteins, including cytoskeletal proteins, and activation of the proteostasis network . Noise overexposure also has auditory, psychological, and physiological effects, including the overproduction of stress hormones and impairment of cellular immunity . The mechanisms of cochlear damage in noise-induced hearing loss involve calcium influx, generation of reactive oxygen species, and activation of cell death pathways . Mechanical stress to cochlear structures, particularly the basilar membrane, is the major pathological basis of noise-induced hearing loss . Acoustic overstimulation causes complex molecular changes in the cochlea, leading to morphological and biological alterations that compromise cochlear function .
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25 Citations | The mechanism of noise damage to the cochlea involves calcium influx, generation of reactive oxygen species, vasoconstriction, and excitotoxic reactions at the inner hair cell synapse. |
| The mechanism of cochlear damage in noise-induced hearing loss is not specified in the provided information. | |
28 Citations | Exposure to loud noise causes proteotoxicity in the cochlea, leading to accumulation of proteins and activation of the proteostasis network. |
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