What will happen if an antagonistic compound disrupts the cellular machinery and prohibits the production of mRNA?
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If an antagonistic compound disrupts the cellular machinery and prohibits the production of mRNA, it can have several consequences. One consequence is the activation of the tumour-suppressor p53, which leads to an increase in p53 transcriptional activity and can result in p53-dependent G1 cell cycle arrest . Additionally, interfering with the spliceosome, a key component of the splicing machinery, can cause an increase in the rate of degradation of Mdm2, a key repressor of p53, leading to p53 activation . Furthermore, the accumulation of chemically damaged mRNA can disrupt cellular homeostasis, leading to the activation of the mRNA-surveillance pathway and ribosome-quality control mechanisms . Finally, inhibiting pre-mRNA 3' processing can have sequence-specific effects, impacting poly(A) site selection and transcription termination . These findings highlight the importance of proper mRNA production and processing for cellular function and suggest potential therapeutic strategies for targeting mRNA-related processes in disease .
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| If an antagonistic compound disrupts the cellular machinery and prohibits the production of mRNA, it could potentially inhibit protein synthesis and disrupt cellular functions. | |
49 Citations | If an antagonistic compound disrupts the cellular machinery and prohibits the production of mRNA, it can lead to the accumulation of damaged mRNA and aberrant protein products. |
135 Citations | If an antagonistic compound disrupts the cellular machinery and prohibits the production of mRNA, it may inhibit viral infection and restore proper antiviral host gene expression. |
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