K
Ke Zhang
Researcher at University of Texas Southwestern Medical Center
Publications - 21
Citations - 1053
Ke Zhang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Influenza A virus & Nuclear export signal. The author has an hindex of 11, co-authored 19 publications receiving 664 citations. Previous affiliations of Ke Zhang include Chinese Academy of Sciences & Sichuan University.
Papers
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Journal ArticleDOI
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Lisa Miorin,Thomas Kehrer,Maria Teresa Sánchez-Aparicio,Ke Zhang,Phillip Cohen,Roosheel S. Patel,Anastasija Cupic,Tadashi Makio,Menghan Mei,Elena Moreno,Oded Danziger,Kris M. White,Raveen Rathnasinghe,Melissa B. Uccellini,Shengyan Gao,Teresa Aydillo,Ignacio Mena,Xin Yin,Laura Martin-Sancho,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Sumit K. Chanda,Michael Schotsaert,Richard W. Wozniak,Yi Ren,Brad R. Rosenberg,Beatriz M. A. Fontoura,Adolfo García-Sastre +28 more
TL;DR: SARS-CoV-2 is able to efficiently block STAT1 and STAT2 nuclear translocation in order to impair transcriptional induction of IFN-stimulated genes (ISGs).
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Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.
Ke Zhang,Lisa Miorin,Tadashi Makio,Ishmael Dehghan,Shengyan Gao,Yihu Xie,Hualin Zhong,Matthew Esparza,Thomas Kehrer,Anil Kumar,Tom C. Hobman,Christopher Ptak,Boning Gao,John D. Minna,Zhijian J. Chen,Adolfo García-Sastre,Yi Ren,Richard W. Wozniak,Beatriz M. A. Fontoura +18 more
TL;DR: In this paper, the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host mRNA export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular mRNAs.
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Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication.
Xiaoling Liu,Lei Sun,Maorong Yu,Zengfu Wang,Chongfeng Xu,Qinghua Xue,Ke Zhang,Xin Ye,Yoshihiro Kitamura,Wenjun Liu +9 more
TL;DR: The mutagenesis results and immunofluorescence assays indicated that CypA interacted with the M1 protein and affected the early stage of the viral replication.
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Influenza virus mRNA trafficking through host nuclear speckles.
Amir Mor,Alexander D. White,Ke Zhang,Matthew G. Thompson,Matthew Esparza,Raquel Muñoz-Moreno,Kazunori Koide,Kristen W. Lynch,Adolfo García-Sastre,Adolfo García-Sastre,Beatriz M. A. Fontoura +10 more
TL;DR: It is shown that the influenza virus uses nuclear speckles to promote post-transcriptional splicing of its M1 mRNA, and previously unknown roles for the viral NS1 protein and cellular factors are assigned to an intranuclear trafficking pathway.
Journal ArticleDOI
Identification and Characterization of Three Novel Nuclear Export Signals in the Influenza A Virus Nucleoprotein
Maorong Yu,Xiaoling Liu,Shuai Cao,Zhendong Zhao,Ke Zhang,Qing Xie,Caiwei Chen,Shengyan Gao,Yuhai Bi,Lei Sun,Xin Ye,George F. Gao,Wenjun Liu +12 more
TL;DR: Three novel nuclear export signals of the NP—NES1, NES2, and NES3—were identified as being responsible for mediating its nuclear export and functional studies indicated that oligomerization is also required for nuclear export of NP.