Which immune-related diseases or conditions are most likely to respond positively to lectin-based immunomodulatory therapies?
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Lectin-based immunomodulatory therapies show promise in treating autoimmune diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes (T1D), and systemic sclerosis (SSc) by regulating immune responses and cell functions . Additionally, lectins have demonstrated anti-HIV properties and potential in targeting coinfecting pathogens in HIV-infected individuals, suggesting their utility in combating HIV/AIDS and concomitant infections . In the context of multiple sclerosis (MS), the C-type lectin receptor MGL has shown to play a crucial role in dampening autoimmune-driven neuroinflammation by inducing apoptosis of autoreactive T cells and reducing pro-inflammatory responses, indicating its potential as an anti-inflammatory therapeutic target for MS and other neuroinflammatory conditions . Overall, lectin-based immunomodulatory therapies hold promise in addressing a range of immune-related diseases and conditions by modulating immune responses and targeting specific pathological mechanisms.
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| Papers (4) | Insight |
|---|---|
| Lectin-based immunomodulatory therapies show promise in autoimmune neuroinflammation, such as multiple sclerosis, by dampening pathogenic T and B cell responses, suggesting efficacy in similar immune-related conditions. | |
| Lectin-based therapies show promise in treating HIV and potential coinfections like other enveloped viruses, bacteria, yeasts, fungi, and protozoa, making them beneficial for immune-related diseases. | |
14 Citations | Not addressed in the paper. |
3 Citations | Galectin-1 and galectin-3 show therapeutic potential in autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and systemic sclerosis, suggesting positive responses to lectin-based immunomodulatory therapies. |
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