J
Juan J. Garcia-Vallejo
Researcher at VU University Amsterdam
Publications - 109
Citations - 5990
Juan J. Garcia-Vallejo is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 39, co-authored 102 publications receiving 4195 citations. Previous affiliations of Juan J. Garcia-Vallejo include University of Málaga & University of Amsterdam.
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Journal ArticleDOI
Discovery and quantification of plastic particle pollution in human blood.
Heather A. Leslie,Martin van Velzen,Sicco H. Brandsma,A. Dick Vethaak,Juan J. Garcia-Vallejo,Marja H. Lamoree +5 more
TL;DR: In this paper , the authors developed a robust and sensitive sampling and analytical method with double shot pyrolysis - gas chromatography/mass spectrometry and applied it to measure plastic particles ≥700 nm in human whole blood from 22 healthy volunteers.
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Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
Diego O. Croci,Juan P. Cerliani,Tomás Dalotto-Moreno,Santiago P. Méndez-Huergo,Ivan D. Mascanfroni,Sebastián Dergan-Dylon,Marta A. Toscano,Julio J. Caramelo,Juan J. Garcia-Vallejo,Jing Ouyang,Enrique A. Mesri,Melissa R. Junttila,Carlos Bais,Margaret A. Shipp,Mariana Salatino,Gabriel A. Rabinovich,Gabriel A. Rabinovich +16 more
TL;DR: A glycosylation-dependent pathway is identified that compensates for the absence of cognate ligand and preserves angiogenesis in response to VEGF blockade and may increase the efficacy of anti-VEGF treatment.
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Neuroinflammation: Microglia and T Cells Get Ready to Tango.
TL;DR: Recent findings that unite the paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases are reviewed, providing an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.
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Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling
Frederik J. Verweij,Frederik J. Verweij,Frederik J. Verweij,Maarten P. Bebelman,Maarten P. Bebelman,Connie R. Jimenez,Juan J. Garcia-Vallejo,Hans Janssen,Jacques Neefjes,Jaco C. Knol,Richard de Goeij-de Haas,Sander R. Piersma,S. Rubina Baglio,Matthijs Verhage,Matthijs Verhage,Jaap M. Middeldorp,Anoek Zomer,Jacco van Rheenen,Marc G. Coppolino,Ilse Hurbain,Ilse Hurbain,Graça Raposo,Graça Raposo,Martine J. Smit,Ruud F. Toonen,Ruud F. Toonen,Guillaume van Niel,Guillaume van Niel,D. Michiel Pegtel +28 more
TL;DR: In this article, a tetraspanin-based pH-sensitive optical reporter was designed to detect multivesicular bodies (MVBs) fusion using live total internal reflection fluorescence and dynamic correlative light-electron microscopy.
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Dendritic cells and C‐type lectin receptors: coupling innate to adaptive immune responses
TL;DR: How specific glycosylation of antigens can dictate both the innate and adaptive interactions that are mediated by CLRs on DCs and how this balances immune activation and inhibition of DC function is discussed.