Showing papers on "Biflavonoid published in 2004"
TL;DR: The in vivo carrageenan induced paw edema assay resulted in dose dependent anti-inflammatory effect of THA and the activity was comparable to that of ibuprofen, one of the well known NSAIDs.
78 citations
TL;DR: The methanolic extract of the leaves of the medicinal plant Byrsonima crassa (Malpighiaceae) contain flavonoids with antioxidant activity that were separated using high-speed counter-current chromatography and identified by 1H NMR, 13C NMR and UV analyses.
63 citations
TL;DR: The Suzuki coupling reaction was used to synthesize 6-iodonated biflavonoid as mentioned in this paper, which was regioselectively synthesized by the use of AgOAc/I2 under mild conditions without handling of a strongly toxic reagent.
34 citations
TL;DR: Amentoflavone was found to degrade calf thymus DNA in the presence of Cu(II) at a rate almost twice that of apigenin, indicating that the biflavonoid is capable of binding to copper ions.
30 citations
TL;DR: Lanaroflavone showed both antimalarial and leishmanicidal activities, but was inactive against Chagas disease vector, Trypanosoma cruzi.
21 citations
TL;DR: The isolation of a new biflavonoid from the leaves of Garcinia nervosa is reported and the structure was established by chemical and physical means.
12 citations
01 Jan 2004
TL;DR: In this paper, a new biflavonoid, stelleranol, was isolated from the roots of Stellera chamaejasme L. Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra.
Abstract: A new biflavonoid, stelleranol, was isolated from the roots of Stellera chamaejasme L..Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra.
6 citations
TL;DR: In this article, the PM3 semi-empirical method was employed to calculate a set of molecular properties (variables or descriptors) of 28 biflavonoid compounds with inhibitory activity against Mycobacterium tuberculosis H37Rv (Mtb).
Abstract: Biflavonoids are a series of naturally occurring with a variety of biological activities. In this work the PM3 semi-empirical method was employed to calculate a set of molecular properties (variables or descriptors) of 28 biflavonoid compounds with inhibitory activity against Mycobacterium tuberculosis H37Rv (Mtb). We have observed a correlation between the heat of formation (Hf), log of the octanol/water partition coefficient ( log P) or hydration energy (HE) and the antituberculosis activity. The active compounds present larger values for log P, Hf, and HE. These results suggest that it is possible, in principle, to select the most (or the least) promising molecules from a series of untested biflavonoid molecules, simply by comparing their Hf, log P, or HE.
5 citations
TL;DR: A novel biflavonoid named licobichalcone was isolated from the roots of Glycyrrhiza uralensis cultivated in China, along with twelve known compounds, including five chalcones, two isoflavones, two flavanones and two flavones and one pterocarpan as discussed by the authors.
Abstract: A novel biflavonoid named licobichalcone was isolated from the roots of Glycyrrhiza uralensis cultivated in China, along with twelve known compounds, including five chalcones, two isoflavones, two flavanones, two flavones and one pterocarpan. Their structures were respectively elucidated on the basis of chemical and spectroscopic evidence.
4 citations
TL;DR: A set of 14 biflavonoid compounds with anti-human immunodeficiency virus (anti-HIV) activity is studied by using quantum chemical and chemometric methodologies with the aim to calculate some molecular properties and correlate them with the biological activity.
Abstract: A set of 14 biflavonoid compounds with anti-human immunodeficiency virus (anti-HIV) activity is studied by using quantum chemical and chemometric methodologies with the aim to calculate some molecular properties and correlate them with the biological activity. The AM1 semi-empirical method was used to calculate the molecular properties of the 14 biflavonoid compounds and the chemometric methods stepwise discriminant analysis (SDA), K-nearest neighbours (KNN) and soft independent modelling of class analogy (SIMCA) were used to obtain the relationship between the calculated properties and the biological activity under study. Afterwards we used the results obtained with SDA, KNN and SIMCA to predict the anti-HIV activity of a new set of biflavonoid molecules.
4 citations