Showing papers on "Campesterol published in 1989"
TL;DR: The study emphasizes that, in normal men, high serum cholestanol levels reflect high efficiency of intestinal sterol absorption and low cholesterol synthesis, which is parallel with those of plant sterols and opposite to those of cholesterol precursor sterols.
Abstract: Serum cholestanol was studied in relation to fecal cholestanol excretion and cholesterol metabolism in a random middle-aged population of 61 men. The serum concentrations of cholestanol ranged from 1.6 to 10.8 mumol/L and were positively correlated with those of serum total LDL and HDL cholesterol. In terms of millimole per mole of cholesterol, these correlations disappeared; inverse associations were found with VLDL cholesterol and triglyceride levels, the P/S ratio of dietary fat, and the amount of fecal plant sterols, but not with fecal cholestanol. The serum contents of cholestanol (1) were also closely positively associated with those of serum plant sterols (campesterol and sitosterol) and fractional cholesterol absorption, (2) were inversely related to the fecal excretion of neutral sterols and cholesterol synthesis which were measured either by the sterol balance technique or serum cholesterol precursor sterols (desmosterol and lathosterol), and (3) were unrelated to bile acid synthesis. Fecal cholestanol (mean = 12.5 mg/d) was (1) clearly higher than the dietary cholestanol intake (less than 2 mg/d), (2) unrelated to serum cholestanol, and (3) positively correlated with the intestinal cholesterol (dietary plus endogenous) flux as well as fecal plant sterols, neutral sterols, and bacterial products of cholesterol. The study emphasizes that, in normal men, high serum cholestanol levels reflect high efficiency of intestinal sterol absorption and low cholesterol synthesis. Thus, the changes in the serum contents of cholestanol are parallel with those of plant sterols and opposite to those of cholesterol precursor sterols.
203 citations
TL;DR: It is suggested that dietary phytosterol modulates desaturase activities, which make the membrane more rigid but do not induce changes in the relative phospholipid composition.
80 citations
Journal Article•
TL;DR: The investigation on steroidic fraction of Uncaria tomentosa showed the presence of beta-sitosterol (60%), stigmasterol, and campesterol, which preliminary pharmacological investigations prove a moderate antiinflammatory activity.
Abstract: The investigation on steroidic fraction of Uncaria tomentosa, commonly called Una de gato, showed the presence of beta-sitosterol (60%), stigmasterol, and campesterol. The percentage of sterols have been carried out by GLC. The spectroscopic data 1H-NMR and MS of the three compounds are also reported, with the beta-sitosterol as the main sterol. Preliminary pharmacological investigations prove a moderate antiinflammatory activity.
29 citations
TL;DR: It is suggested that poor esterification of plant sterols may contribute to the decrease in hepatic and serum levels of sitosterol and campesterol in the rat, and that activation of hepatic sterol production leads to depletion of liver-based phytosterols.
Abstract: Hepatic and serum phytosterol concentrations were compared in the rat under basal conditions and during activated cholesterol and bile acid production due to squalene and cholestyramine feeding. Both treatments consistently decreased hepatic and serum levels of sitosterol and campesterol and, unlike esterified cholesterol, esterified plant sterols were not increased in liver during squalene feeding. Serum levels of phytosterols were decreased quite proportionately to those in the liver. The hepatic levels of sitosterol and campesterol closely correlated with each other, but not with cholesterol levels. The percentage esterification of both phytosterols was lower than that of cholesterol. The results indicate that activation of hepatic sterol production leads to depletion of hepatic plant sterols. It is suggested that poor esterification of plant sterols may contribute to this decrease.
24 citations
Journal Article•
TL;DR: In this paper, the seed oil of Renealmia alpinia Maas (Zingiberaceae) was analyzed for glycerides and sterols, showing that triacyl glycerols were the main glyceridic constituents.
Abstract: Seed oil of Renealmia alpinia Maas (Zingiberaceae) was analysed for glycerides and sterols. TLC of lipid classes showed that triacylglycerols were the main glyceridic constituents. GLC of fatty acids revealed the presence of 14 compounds. Fractionation of the unsaponifiable indicated the presence of sterols, methylsterols and triterpenic alcohols. GCMS and GLC analysis demonstrated that cholesterol, campesterol, stigmasterol, β-sitosterol, were the main sterolic molecules
11 citations
TL;DR: In this paper, the silylation of a plant sterol mixture directly on the silica gel after purification by thin layer chromatography was applied to sterols extracted from strawberry fruits and an unknown, tentatively identified as isofucosterol, were the main free sterols in the strawberry fruits.
10 citations
TL;DR: Observations suggest an increased cholesterol synthesis upon treatment with activated charcoal, probably caused by the interference with the enterohepatic circulation of bile acids in patients with primary hypercholesterolaemia.
Abstract: The hypocholesterolaemic mechanism of activated charcoal was studied in seven patients with primary hypercholesterolaemia. The reduction of serum cholesterol was correlated with the serum concentrations of cholesterol precursors and of two plant sterols. Activated charcoal, 8 g t.i.d. for 4 weeks, reduced serum concentration of total cholesterol by 27% (P less than 0.01). The effect was accompanied by a moderate elevation (P less than 0.05) in serum squalene and desmosterol concentrations and by a marked increase (up to 300-700%) in serum lathosterol and delta 8 lathosterol concentrations. The levels of two plant sterols, campesterol and beta-sitosterol, were unchanged or only slightly decreased by the use of activated charcoal. The decrease of serum cholesterol concentration had significant negative correlations with serum lathosterol and delta 8 lathosterol, and significant positive correlations with serum cholestanol and beta-sitosterol. These observations suggest an increased cholesterol synthesis upon treatment with activated charcoal, probably caused by the interference with the enterohepatic circulation of bile acids.
8 citations
TL;DR: The discrepancy between cholesterol values measured by GLC, the presumed method of choice, and cholesterol content of foods calculated from food tables is large and presents a major problem in the accurate assessment of dietary cholesterol.
8 citations
TL;DR: Panagrellus redivivus is capable of reducing the Δ5-bond, C−24 dealkylation and methylating the sterol nucleus at C−4, and was propagated in media containing three structurally different sterols: 7-dehydrocholesterol, campesterol or stigmastanol.
Abstract: Panagrellus redivivus was propagated in media containing three structurally different sterols: 7-dehydrocholesterol, campesterol or stigmastanol. Nematodes propagated with 7-dehydrocholesterol contained mostly lathosterol and 7-dehydrocholesterol. Nematodes propagated with campesterol contained mostly cholesterol and cholestanol. Nematodes propagated with stigmastanol contained mostly cholestanol. The sterol ester fraction was enriched with 4α-methylsterols and contained the same sterols as the free sterol fraction except for nematodes propagated with 7-dehydrocholesterol, where no dietary sterol was found in the ester fraction.P. redivivus is capable of reducing the Δ5-bond, C−24 dealkylation and methylating the sterol nucleus at C−4.
6 citations
TL;DR: In this paper, four steroids were isolated from lemon peels and their structures were established by MS, 1H-NMR and 13C-nMR spectroscopy. But none of them were found in lemons.
Abstract: During the course of our studies on physiologyically active substances in citrus fruit peelings, four steroids were isolated from lemon peels. Their structures were established by MS, 1H-NMR and 13C-NMR spectroscopy. They were β-sitosterol [1], campesterol [2], stigmasterol [3] and 4, 4-dimethylcholest-5-ene-3-β-ol[4]. Among these compounds, [2], [3] and [4] were found in lemon peels for the first time.
1 citations