Showing papers on "Prallethrin published in 2018"
TL;DR: The vapor toxicity for the aforementioned compounds significantly exceeds prallethrin, which is currently market available as an adulticidal active ingredient in public health pest control and should be considered for further development.
Abstract: BACKGROUND Mosquito mortality has been documented in numerous studies of spatial repellents but the concentration-dependent toxicity of spatial repellent vapors has not been documented. To address this issue, prallethrin, flumethrin, metofluthrin, transfluthrin, and meperfluthrin were selected for comparative study against Aedes albopictus (Skuse), Ae. aegypti (L.), Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say. Mosquito were exposed to vapors of each chemical for 2, 4, and 24 h with mortality recorded at each time point. A second experiment involved exposing mosquitoes to vapors for 2 h, then transferring them to untreated holding containers and held for 24 h. For these mosquitoes, readings were only taken after 24 h to allow for metabolic detoxification and recovery. RESULTS LC50 and LC90 data indicated that transfluthrin and meperfluthrin had the greatest toxicity across all species, followed by metofluthrin, prallethrin, and flumethrin. CONCLUSION Our findings, through the direct comparison of these compounds, suggest that transfluthrin, meperfluthrin, and metofluthrin be considered for further development. The vapor toxicity for the aforementioned compounds significantly exceeds prallethrin, which is currently market available as an adulticidal active ingredient in public health pest control. © 2018 Society of Chemical Industry.
25 citations
TL;DR: It is first to describe that allethrin and prallethrin-induced MUC5AC expression through ROS in human airway epithelial cells is described.
11 citations
TL;DR: The findings suggest that proper application of truck based insecticides for mosquito control results in little or no exposure and therefore minimal effects on domestic honey bees.
Abstract: Few studies have examined the impact of mosquito adulticides on honey bees under conditions that reflect actual field exposure. Whereas several studies have evaluated the toxicity of mosquito control products on honey bees, most have been laboratory based and have focused solely on acute mortality as a measure of impact. The goal of this study was to determine effects of routine applications of truck-based ultra-low volume (ULV) mosquito adulticides (i.e., Scourge, Duet, and Deltagard) on honey bees in a suburban setting. The mosquito adulticides used in this study were pyrethroids with active ingredients resmethrin (Scourge), prallethrin and sumithrin (Duet), and deltamethrin (Deltagard), in which resmethrin, prallethrin, and sumithrin were synergized with piperonyl butoxide. We measured and compared mortality and detoxification enzyme activities (esterase and glutathione S-transferase) from sentinel beehives within and outside of mosquito control areas. Concurrently, colony health (i.e., number of adult bees, brood quantity and brood quality) was compared throughout the study period. No significant differences were observed in honey bee mortality, colony health or detoxification enzyme activities between treated (five sprayed areas each received one to three insecticide treatment) and control sites (four unsprayed areas that did not receive insecticide treatment) over the seven week study period. However, our laboratory study showed that exposure to resmethrin, the active ingredient in Scourge, caused significant inhibition of esterase activity compared with the control group. Our findings suggest that proper application of truck based insecticides for mosquito control results in little or no exposure and therefore minimal effects on domestic honey bees.
9 citations
TL;DR: It is demonstrated that metofluthrin can induce high insecticidal activity in Ae.
Abstract: The bioefficacy of commercial mosquito coils containing four different active ingredients, namely metofluthrin, d-allethrin, d-trans allethrin, and prallethrin against Aedes albopictus (Skuse) (Diptera: Culicidae) from 10 states in Malaysia, was evaluated using the glass chamber method. In this study, Ae. albopictus exhibited various knockdown rates (50% knockdown time, KT50), ranging from 2.50 to 5.00 min, 2.50 to 7.00 min, 3.00 to 8.00 min, and 5.00 to 17.00 min for metofluthrin, d-trans allethrin, d-allethrin, and prallethrin, respectively. Overall, all strains of Ae. albopictus were most susceptible to metofluthrin, with mortality rates >80%. On the other hand, mortality rates ranging from 5.0 to 100% were observed from all populations exposed to d-trans allethrin, d-allethrin, and prallethrin. In addition, significant correlations between KT50 of metofluthrin and d-allethrin (r = 0.758, P = 0.011), metofluthrin and prallethrin (r = 0.676, P = 0.032), d-allethrin and d-trans allethrin (r = 0.832, P = 0.003), d-allethrin and prallethrin (r = 0.921, P = 0.000), and d-trans allethrin with prallethrin (r = 0.941, P = 0.000) were detected, suggesting some levels of cross-resistance within the pyrethroid insecticides. This study demonstrated that metofluthrin can induce high insecticidal activity in Ae. albopictus in Malaysia, followed by d-trans allethrin, d-allethrin, and prallethrin.
5 citations
TL;DR: Comparative bio-efficacy of multiple polyfluorobenzyl pyrethroids and PBO synergism against mosquitoes is reported, which supports the hypothesis that P450 enzymes could play a role in the detoxification process of transfluthrin.
Abstract: Intensive exposure to insecticides has resulted in the evolution of insecticide resistance in the mosquitoes. We tested the bio-efficacy of two Culex quinquefasciatus Say (Diptera: Culicidae) laboratory strains differentially bio-responsive to pyrethroids to understand the comparative efficacy of different polyfluorobenzyle and conventional pyrethroid molecules and the role of piperonyl butoxide (PBO) in synergizing these molecules in increased tolerance of mosquitoes to these molecules. We have taken deltamethrin (α-cyano pyrethroid with phenoxybenzyl moiety); permethrin (phenoxybenzyl pyrethroid without an α-cyano group); transfluthrin, dimefluthrin, metofluthrin, and meperfluthrin (polyfluorinated benzyl compounds); and prallethrin (modified cyclopentadienone compound) for this study. We found higher bio-efficacy in dimefluthrin, metofluthrin, and meperfluthrin compared with transfluthrin against tested mosquito strains. We found that transfluthrin exhibited synergism with PBO, which supports the hypothesis that P450 enzymes could play a role in the detoxification process of transfluthrin, which was earlier not believed. However, other polyfluorobenzyl pyrethroids with a 4-(methoxymethyl) phenyl capping in the tetrafluorobenzyl ring (dimefluthrin, metofluthrin, and meperfluthrin) exhibit greater synergism with PBO compared with transfluthrin. Further study is required to understand the mechanism for higher synergistic ratios in polyfluorobenzyl pyrethroids with 4-(methoxymethyl) phenyl moiety and ascertain the possible involvement of novel mechanisms that may involve in developing resistance. This is the first report of comparative bio-efficacy of multiple polyfluorobenzyl pyrethroids and PBO synergism against mosquitoes.
5 citations
1 citations
Patent•
04 Dec 2018
TL;DR: In this paper, a mosquito repellent liquid consisting of 10-20 parts of deet, 5-15 parts of prallethrin, 10-30 parts of a surfactant and 5-10 parts of an antiseptic was presented.
Abstract: The invention discloses a mosquito repellent liquid and a preparation method thereof The mosquito repellent liquid consists of, by weight, 10-20 parts of deet, 5-15 parts of prallethrin, 10-30 partsof a surfactant, 5-10 parts of an antiseptic, 5-10 parts of an anti-freezing agent and 60-90 parts of water The preparation method includes the following steps: (1) by weight, adding the 10-30 partsof the surfactant, the 5-10 parts of the antiseptic and the 5-10 parts of the anti-freezing agent into the 60-90 parts of the water in order, stirring the mixture to achieve complete dissolution; and(2) adding the 10-20 parts of the deet and the 5-15 parts of the prallethrin into a solution obtained by the step (1), and performing constant temperature stirring so that a finished product can be obtained The prepared mosquito repellent liquid can rapidly and efficiently kill mosquitos
1 citations
Patent•
22 Nov 2018TL;DR: In this paper, a composite insecticidal composition is disclosed that contains three active ingredients, which are transfluthrin, prallethrin, and cypermethrin, which may further contain at least one of a solvent and a propellant.
Abstract: A composite insecticidal composition is disclosed that contains three active ingredients, which are transfluthrin, prallethrin, and cypermethrin. The composite insecticide composition may further contain at least one of a solvent and a propellant. The weight percentage of each of the active ingredients may be about 0.05% to 0.5%.
Patent•
29 Nov 2018
TL;DR: In this article, a composite insecticidal composition is disclosed that contains three active ingredients, which are transfluthrin, prallethrin, and cypermethrin, which may further contain at least one of a solvent and a propellant.
Abstract: A composite insecticidal composition is disclosed that contains three active ingredients, which are transfluthrin, prallethrin, and cypermethrin The composite insecticide composition may further contain at least one of a solvent and a propellant The weight percentage of each of the active ingredients may be about 005% to 05%